Version: 8.0.0
Date: Tue Jan 28 2025
Tnf
Rattus norvegicusRGD:3876
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Tnf

Species
Rattus norvegicus
Symbol
Tnf
Name
tumor necrosis factor
Synonyms
  • cachectin
  • LOC103694380
Biotype
protein coding gene
Automated Description
Enables tumor necrosis factor receptor binding activity. Involved in several processes, including negative regulation of transport; positive regulation of cell communication; and positive regulation of macromolecule biosynthetic process. Acts upstream of or within positive regulation of interleukin-6 production. Located in external side of plasma membrane; extracellular space; and neuronal cell body. Is active in extracellular region. Used to study several diseases, including cerebrovascular disease (multiple); liver disease (multiple); peptic esophagitis; perinatal necrotizing enterocolitis; and periventricular leukomalacia. Biomarker of several diseases, including artery disease (multiple); brain disease (multiple); congestive heart failure (multiple); liver disease (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); liver disease (multiple); lung disease (multiple); and skin disease (multiple). Orthologous to human TNF (tumor necrosis factor).
RGD Description
Enables tumor necrosis factor receptor binding activity. Involved in several processes, including negative regulation of transport; positive regulation of cell communication; and positive regulation of macromolecule metabolic process. Acts upstream of or within positive regulation of interleukin-6 production. Located in external side of plasma membrane; extracellular space; and neuronal cell body. Is active in extracellular region. Used to study several diseases, including cerebrovascular disease (multiple); liver disease (multiple); peptic esophagitis; perinatal necrotizing enterocolitis; and periventricular leukomalacia. Biomarker of several diseases, including artery disease (multiple); brain disease (multiple); congestive heart failure (multiple); liver disease (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); lung disease (multiple); and skin disease (multiple). Orthologous to human TNF (tumor necrosis factor); PARTICIPATES IN pro-inflammatory cytokine mediated pathway; ceramide signaling pathway; Fc epsilon receptor mediated signaling pathway; INTERACTS WITH (+)-catechin; (+)-pilocarpine; (+)-taxifolin.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11471
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Tnf molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Tnf role
            Tnf genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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