Gene

Htr2b

Species
Rattus norvegicus
Symbol
Htr2b
Name
5-hydroxytryptamine receptor 2B
Synonyms
  • 5-HT-2B
  • 5-HT-2F
Biotype
protein coding gene
Automated Description
Enables serotonin binding activity. Involved in several processes, including cellular response to serotonin; hepatic stellate cell activation; and inositol phosphate metabolic process. Located in dendrite; neuronal cell body; and plasma membrane. Used to study heart valve disease. Biomarker of brain infarction and congestive heart failure. Human ortholog(s) of this gene implicated in metabolic dysfunction-associated steatohepatitis and steatotic liver disease. Orthologous to human HTR2B (5-hydroxytryptamine receptor 2B).
RGD Description
Enables serotonin binding activity. Involved in several processes, including cellular response to serotonin; hepatic stellate cell activation; and inositol phosphate metabolic process. Located in dendrite; neuronal cell body; and plasma membrane. Used to study heart valve disease. Biomarker of brain infarction and congestive heart failure. Human ortholog(s) of this gene implicated in metabolic dysfunction-associated steatohepatitis and steatotic liver disease. Orthologous to human HTR2B (5-hydroxytryptamine receptor 2B); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH (R)-noradrenaline; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24247
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensHTR2B10 of 10YesYes  
Mus musculusHtr2b9 of 9YesYes   
Xenopus tropicalishtr2b2 of 9YesYes   
Danio reriohtr2b9 of 9YesYes   
Drosophila melanogaster5-HT2B3 of 9YesNo   
Drosophila melanogaster5-HT2A3 of 9YesYes   
Caenorhabditis elegansser-13 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Htr2a144860456 of 9 
Htr2c237867495 of 9 
Htr7342549283 of 9 
Htr1f440949283 of 9 
Htr1a538848323 of 9 
Drd4639949322 of 9 
Htr1b739948283 of 9 
Htr6845544272 of 9 
Drd1944744282 of 9 
Htr1d1039048313 of 9 
Chrm51153936222 of 9 
Htr41239948302 of 9 
Hrh11348341232 of 9 
Htr5a1440147263 of 9 
Chrm41548939232 of 9 
Chrm11642443262 of 9 
Htr5b1733848283 of 9 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
mRatBN7.2
Viewer Help
86.736M86.738M86.740M86.742M86.744M86.746M86.748M86.750M86.752M86.754M86.756M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
NC_051344.1:g.86736340C>Tvariant
SNP
  • intron variant
NC_051344.1:g.86739462A>Tvariant
SNP
  • intron variant
NC_051344.1:g.86755494C>Avariant
SNP
  • intron variant
NC_051344.1:g.86743094T>Cvariant
SNP
  • synonymous variant
NC_051344.1:g.86743841T>Cvariant
SNP
  • intron variant
NC_051344.1:g.86745749T>Avariant
SNP
  • intron variant
NC_051344.1:g.86752701T>Cvariant
SNP
  • intron variant
NC_051344.1:g.86753068G>Cvariant
SNP
  • intron variant
NC_051344.1:g.86753679A>Cvariant
SNP
  • intron variant
NC_051344.1:g.86745076T>Gvariant
SNP
  • intron variant
Showing 1 - 10 of 75 rows
per page

Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
86.736M86.738M86.740M86.742M86.744M86.746M86.748M86.750M86.752M86.754M86.756MENSRNOT00000023829.5 (Htr2b)NM_017250.2 (Htr2b)XM_039083116.2 (Htr2b)ENSRNOT00000024306.6 (Psmd1)ENSRNOT00000089470.2 (Psmd1)ENSRNOT00000099829.1 (Psmd1)NM_031978.2 (Psmd1)

Sequence Details

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Expression

Primary Sources
None
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

2 interactor genes based on 2 annotations
Htr2b molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
Agtr1aRattus norvegicus
protein
  • affinity chromatography technology
PMID:19023134
protein
NOS1Homo sapiens
protein
  • pull down
PMID:17161399
Showing 1 - 2 of 2 rows
per page

Genetic Interactions

No data available