Gene

Htr2b

Species
Rattus norvegicus
Symbol
Htr2b
Name
5-hydroxytryptamine receptor 2B
Synonyms
  • 5-HT-2B
  • 5-HT-2F
Biotype
protein coding gene
Automated Description
Enables serotonin binding activity. Involved in several processes, including cellular response to serotonin; hepatic stellate cell activation; and inositol phosphate metabolic process. Located in dendrite; neuronal cell body; and plasma membrane. Used to study heart valve disease. Biomarker of brain infarction and congestive heart failure. Human ortholog(s) of this gene implicated in metabolic dysfunction-associated steatohepatitis and steatotic liver disease. Orthologous to human HTR2B (5-hydroxytryptamine receptor 2B).
RGD Description
Enables serotonin binding activity. Involved in several processes, including cellular response to serotonin; hepatic stellate cell activation; and inositol phosphate metabolic process. Located in dendrite; neuronal cell body; and plasma membrane. Used to study heart valve disease. Biomarker of brain infarction and congestive heart failure. Human ortholog(s) of this gene implicated in metabolic dysfunction-associated steatohepatitis and steatotic liver disease. Orthologous to human HTR2B (5-hydroxytryptamine receptor 2B); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH (R)-noradrenaline; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24247
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
86.736M86.738M86.740M86.742M86.744M86.746M86.748M86.750M86.752M86.754M86.756M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions