Gene

Gfer

Species
Rattus norvegicus
Symbol
Gfer
Name
growth factor, augmenter of liver regeneration
Synonyms
  • ALR
  • augmenter of liver regeneration
Biotype
protein coding gene
Automated Description
Enables flavin-dependent sulfhydryl oxidase activity. Involved in several processes, including cellular response to actinomycin D; liver regeneration; and negative regulation of natural killer cell mediated cytotoxicity. Located in extracellular space. Used to study acute kidney failure. Biomarker of acute kidney failure; cryptorchidism; and ureteral obstruction. Human ortholog(s) of this gene implicated in kidney failure and renal fibrosis. Orthologous to human GFER (growth factor, augmenter of liver regeneration).
RGD Description
Enables flavin-dependent sulfhydryl oxidase activity. Involved in several processes, including cellular response to actinomycin D; liver regeneration; and negative regulation of natural killer cell mediated cytotoxicity. Located in extracellular space. Used to study acute kidney failure. Biomarker of acute kidney failure; cryptorchidism; and ureteral obstruction. Human ortholog(s) of this gene implicated in kidney failure and renal fibrosis. Orthologous to human GFER (growth factor, augmenter of liver regeneration); PARTICIPATES IN intermembrane space assembly pathway of mitochondrial protein import; mitochondrial iron-sulfur cluster export pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12645
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
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13.7185M13.7190M13.7195M13.7200M13.7205M13.7210M13.7215M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions