Species

Rattus norvegicus

Symbol

Gria4

Name

glutamate ionotropic receptor AMPA type subunit 4

Synonyms

AMPA-selective glutamate receptor 4
GluA4

Biotype

protein coding gene

Automated Description

Enables AMPA glutamate receptor activity and identical protein binding activity. Involved in chemical synaptic transmission; positive regulation of glutamatergic synaptic transmission; and response to fungicide. Located in several cellular components, including dendritic spine; neuronal cell body; and postsynaptic density. Part of AMPA glutamate receptor complex and kainate selective glutamate receptor complex. Is active in glutamatergic synapse; postsynaptic density membrane; and presynaptic active zone membrane. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human GRIA4 (glutamate ionotropic receptor AMPA type subunit 4).

RGD Description

Enables AMPA glutamate receptor activity and identical protein binding activity. Involved in chemical synaptic transmission; positive regulation of glutamatergic synaptic transmission; and response to fungicide. Located in several cellular components, including dendritic spine; neuronal cell body; and postsynaptic density. Part of AMPA glutamate receptor complex and kainate selective glutamate receptor complex. Is active in glutamatergic synapse; postsynaptic density membrane; and presynaptic active zone membrane. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human GRIA4 (glutamate ionotropic receptor AMPA type subunit 4); PARTICIPATES IN glutamate signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.

Cross References

Additional Information

Literature

Orthology

Gene tree: PANTHER:PTHR18966

Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse

Paralogy

Function - GO Annotations

Show functions with at least one experimental evidence

Pathways

No data available

Phenotypes

Primary Sources: None
Other Sources: None

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Disease Associations

Include negative annotationsCases where the expected disease association was NOT found

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Alleles and Variants

Allele/Variant Symbol	Allele Synonyms	Category	Variant	Variant type	Molecular consequence	Has Disease Annotations	Has Phenotype Annotations
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Transgenic Alleles

Species (carrying the transgene)	Allele symbol	Transgenic construct	Expressed components	Knock-down targets	Regulatory regions	Has Disease Annotations	Has Phenotype Annotations
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Models

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Sequence Feature Viewer

Genome location

Chr8:1562118...2035035 - (472.92 kb)

Assembly version

mRatBN7.2

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Data currently unavailable; sequence viewer under construction

Sequence Details

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Expression

Primary Sources

None

Other Sources

Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Gria4 molecule type	Interactor gene	Interactor species	Interactor molecule type	Detection method	Source	Reference
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Genetic Interactions

Gria4 role	Gria4 genetic perturbation	Interactor gene	Interactor species	Interactor role	Interactor genetic perturbation	Interaction type	Phenotype or trait	Source	Reference
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