Version: 8.0.0
Date: Tue Jan 28 2025
Ptpn1
Rattus norvegicusRGD:61965
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Ptpn1

Species
Rattus norvegicus
Symbol
Ptpn1
Name
protein tyrosine phosphatase, non-receptor type 1
Synonyms
  • MGC93562
  • protein-tyrosine phosphatase
Biotype
protein coding gene
Automated Description
Enables insulin receptor binding activity; protein phosphatase 2A binding activity; and protein tyrosine phosphatase activity. Involved in several processes, including cellular response to peptide hormone stimulus; positive regulation of apoptotic process; and regulation of protein metabolic process. Located in mitochondrial crista and mitochondrial matrix. Is active in glutamatergic synapse and postsynapse. Biomarker of hyperinsulinism and hypertension. Human ortholog(s) of this gene implicated in coronary artery disease; essential hypertension; and type 2 diabetes mellitus. Orthologous to human PTPN1 (protein tyrosine phosphatase non-receptor type 1).
RGD Description
Enables insulin receptor binding activity; protein phosphatase 2A binding activity; and protein tyrosine phosphatase activity. Involved in several processes, including cellular response to peptide hormone stimulus; positive regulation of apoptotic process; and regulation of protein metabolic process. Located in mitochondrial crista and mitochondrial matrix. Is active in glutamatergic synapse and postsynapse. Biomarker of hyperinsulinism and hypertension. Human ortholog(s) of this gene implicated in coronary artery disease; essential hypertension; and type 2 diabetes mellitus. Orthologous to human PTPN1 (protein tyrosine phosphatase non-receptor type 1); PARTICIPATES IN insulin signaling pathway; epidermal growth factor/neuregulin signaling pathway; insulin-like growth factor signaling pathway; INTERACTS WITH 1,4-dithiothreitol; 17alpha-ethynylestradiol; 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR46900
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Ptpn1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Ptpn1 role
            Ptpn1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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