Version: 8.0.0Date: Tue Jan 28 2025
Gene
Grb2
- Species
- Rattus norvegicus
- Symbol
- Grb2
- Name
- growth factor receptor bound protein 2
- Synonyms
- adapter protein GRB2
- Ash-psi
- Biotype
- protein coding gene
- Automated Description
- Enables several functions, including epidermal growth factor receptor binding activity; insulin receptor substrate binding activity; and phosphotyrosine residue binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; negative regulation of natural killer cell mediated cytotoxicity; and nervous system development. Predicted to act upstream of or within several processes, including embryonic morphogenesis; fibroblast growth factor receptor signaling pathway; and positive regulation of actin filament polymerization. Part of protein-containing complex. Is active in presynapse. Human ortholog(s) of this gene implicated in breast cancer; prostate adenocarcinoma; and prostate cancer. Orthologous to human GRB2 (growth factor receptor bound protein 2).
- RGD Description
- Enables several functions, including epidermal growth factor receptor binding activity; insulin receptor substrate binding activity; and phosphotyrosine residue binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; natural killer cell mediated cytotoxicity; and nervous system development. Predicted to act upstream of or within several processes, including embryonic morphogenesis; fibroblast growth factor receptor signaling pathway; and positive regulation of actin filament polymerization. Part of protein-containing complex. Is active in presynapse. Human ortholog(s) of this gene implicated in breast cancer; prostate adenocarcinoma; and prostate cancer. Orthologous to human GRB2 (growth factor receptor bound protein 2); PARTICIPATES IN insulin signaling pathway; insulin-like growth factor signaling pathway; brain-derived neurotrophic factor signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR46037
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- None
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr10:100869718...100949309 - (79.59 kb)
- Assembly version
- mRatBN7.2
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.