Gene

Abcc4

Species
Rattus norvegicus
Symbol
Abcc4
Name
ATP binding cassette subfamily C member 4
Synonyms
  • ABC-tranporter
  • ATP-binding cassette protein C4
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including ABC-type transporter activity; glutathione transmembrane transporter activity; and prostaglandin transmembrane transporter activity. Involved in several processes, including positive regulation of smooth muscle cell proliferation; response to tetrachloromethane; and response to xenobiotic stimulus. Located in basolateral plasma membrane and external side of apical plasma membrane. Biomarker of cholestasis and extrahepatic cholestasis. Orthologous to human ABCC4 (ATP binding cassette subfamily C member 4 (PEL blood group)).
RGD Description
Predicted to enable several functions, including ABC-type transporter activity; glutathione transmembrane transporter activity; and prostaglandin transmembrane transporter activity. Involved in several processes, including positive regulation of smooth muscle cell proliferation; response to tetrachloromethane; and response to xenobiotic stimulus. Located in basolateral plasma membrane and external side of apical plasma membrane. Biomarker of cholestasis and extrahepatic cholestasis. Orthologous to human ABCC4 (ATP binding cassette subfamily C member 4 (PEL blood group)); PARTICIPATES IN azathioprine pharmacodynamics pathway; lamivudine pharmacokinetics pathway; mercaptopurine pharmacodynamics pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24223
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
95.56M95.58M95.60M95.62M95.64M95.66M95.68M95.70M95.72M95.74M95.76M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions