Version: 8.0.0
Date: Tue Jan 28 2025
Kl
Rattus norvegicusRGD:620396
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Kl

Species
Rattus norvegicus
Symbol
Kl
Name
Klotho
Synonyms
None
Biotype
protein coding gene
Automated Description
Predicted to enable fibroblast growth factor binding activity and fibroblast growth factor receptor binding activity. Involved in several processes, including norepinephrine biosynthetic process; response to angiotensin; and response to vitamin D. Predicted to be located in apical plasma membrane and extracellular region. Used to study familial hyperlipidemia; hypertension; and kidney failure. Biomarker of chronic kidney disease (multiple); hypertension; retinitis pigmentosa; secondary hyperparathyroidism; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in coronary artery disease; intracranial embolism; and spondylosis. Orthologous to human KL (klotho).
RGD Description
Predicted to enable fibroblast growth factor binding activity and fibroblast growth factor receptor binding activity. Involved in several processes, including norepinephrine biosynthetic process; response to angiotensin; and response to vitamin D. Predicted to be located in apical plasma membrane and extracellular region. Used to study familial hyperlipidemia; hypertension; and kidney failure. Biomarker of chronic kidney disease (multiple); hypertension; retinitis pigmentosa; secondary hyperparathyroidism; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in coronary artery disease; intracranial embolism; and spondylosis. Orthologous to human KL (klotho); PARTICIPATES IN fibroblast growth factor signaling pathway; pentose and glucuronate interconversion pathway; starch and sucrose metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10353
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensKL10 of 10YesYes☑☑☑☑☑☑☑☑☑☑  
Mus musculusKl9 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Xenopus tropicaliskl9 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Danio reriokl9 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Drosophila melanogasterCG97014 of 9YesNo☑ ☐☐☐☑☑☑☐☐  
Caenorhabditis elegansklo-14 of 9YesNo☑ ☐☐☐☑☑☑☐☐  
Caenorhabditis elegansklo-24 of 9YesNo☑ ☐☐☐☑☑☑☐☐  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Klb1102264452 of 9☐☐☐☐☐☑☐☑☐ 
Lct2107953374 of 9☑☐☐☐☐☑☑☑☐ 
Gba3348156414 of 9☑☐☐☐☐☑☑☑☐ 
Lctl449953364 of 9☑☐☐☐☐☑☑☑☐ 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
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    Alleles and Variants

    Genome location
    Assembly version
    mRatBN7.2
    Viewer Help
    Data currently unavailable; sequence viewer under construction
    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
    NC_051347.1:g.498791T>Avariant
    SNP
    • intron variant
    NC_051347.1:g.531312A>Cvariant
    SNP
    • 3 prime UTR variant
    NC_051347.1:g.501485T>Cvariant
    SNP
    • intron variant
    NC_051347.1:g.502592T>Avariant
    SNP
    • intron variant
    NC_051347.1:g.523411T>Avariant
    SNP
    • intron variant
    NC_051347.1:g.525456C>Tvariant
    SNP
    • intron variant
    NC_051347.1:g.514619G>Cvariant
    SNP
    • intron variant
    NC_051347.1:g.508841T>Cvariant
    SNP
    • intron variant
    NC_051347.1:g.499904C>Tvariant
    SNP
    • intron variant
    NC_051347.1:g.512261G>Avariant
    SNP
    • intron variant
    Showing 1 - 10 of 103 rows
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    Transgenic Alleles

    No data available

    Models

    No data available

    Sequence Feature Viewer

    Genome location
    Assembly version
    mRatBN7.2
    Viewer Help
    Data currently unavailable; sequence viewer under construction

    Sequence Details

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    Expression

    Primary Sources
    None
    Other Sources
    Must provide at least one subject
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    No data available

    Genetic Interactions

    No data available