Enables several functions, including 2 iron, 2 sulfur cluster binding activity; molybdopterin cofactor binding activity; and oxidoreductase activity, acting on CH or CH2 groups. Involved in several processes, including cellular response to cytokine stimulus; nucleobase-containing small molecule metabolic process; and response to hydrogen peroxide. Located in extracellular space. Is active in cytosol and peroxisome. Used to study several diseases, including hypertension; hyperuricemia; interstitial nephritis; kidney failure (multiple); and renal fibrosis. Biomarker of several diseases, including cholestasis; liver disease (multiple); obesity; pancreatitis; and peritonitis. Human ortholog(s) of this gene implicated in several diseases, including Lesch-Nyhan syndrome; cardiovascular system disease (multiple); chronic kidney disease; hyperuricemia; and xanthinuria type I. Orthologous to human XDH (xanthine dehydrogenase).
RGD Description
Enables several functions, including 2 iron, 2 sulfur cluster binding activity; molybdopterin cofactor binding activity; and oxidoreductase activity, acting on CH or CH2 groups. Involved in several processes, including cellular response to cytokine stimulus; purine nucleobase catabolic process; and purine ribonucleoside catabolic process. Located in extracellular space. Is active in cytosol and peroxisome. Used to study several diseases, including hypertension; hyperuricemia; interstitial nephritis; kidney failure (multiple); and renal fibrosis. Biomarker of several diseases, including cholestasis; liver disease (multiple); obesity; pancreatitis; and peritonitis. Human ortholog(s) of this gene implicated in several diseases, including Lesch-Nyhan syndrome; artery disease (multiple); chronic kidney disease; hyperuricemia; and xanthinuria type I. Orthologous to human XDH (xanthine dehydrogenase); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH (+)-taxifolin; (R)-adrenaline; (R)-lipoic acid.