Gene

Xdh

Species
Rattus norvegicus
Symbol
Xdh
Name
xanthine dehydrogenase
Synonyms
  • xanthine dehydrogenase/oxidase
  • xanthine oxidase
Biotype
protein coding gene
Automated Description
Enables several functions, including 2 iron, 2 sulfur cluster binding activity; molybdopterin cofactor binding activity; and oxidoreductase activity, acting on CH or CH2 groups. Involved in several processes, including cellular response to cytokine stimulus; nucleobase-containing small molecule metabolic process; and response to hydrogen peroxide. Located in extracellular space. Is active in cytosol and peroxisome. Used to study several diseases, including hypertension; hyperuricemia; interstitial nephritis; kidney failure (multiple); and renal fibrosis. Biomarker of several diseases, including cholestasis; liver disease (multiple); obesity; pancreatitis; and peritonitis. Human ortholog(s) of this gene implicated in several diseases, including Lesch-Nyhan syndrome; cardiovascular system disease (multiple); chronic kidney disease; hyperuricemia; and xanthinuria type I. Orthologous to human XDH (xanthine dehydrogenase).
RGD Description
Enables several functions, including 2 iron, 2 sulfur cluster binding activity; molybdopterin cofactor binding activity; and oxidoreductase activity, acting on CH or CH2 groups. Involved in several processes, including cellular response to cytokine stimulus; purine nucleobase catabolic process; and purine ribonucleoside catabolic process. Located in extracellular space. Is active in cytosol and peroxisome. Used to study several diseases, including hypertension; hyperuricemia; interstitial nephritis; kidney failure (multiple); and renal fibrosis. Biomarker of several diseases, including cholestasis; liver disease (multiple); obesity; pancreatitis; and peritonitis. Human ortholog(s) of this gene implicated in several diseases, including Lesch-Nyhan syndrome; artery disease (multiple); chronic kidney disease; hyperuricemia; and xanthinuria type I. Orthologous to human XDH (xanthine dehydrogenase); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH (+)-taxifolin; (R)-adrenaline; (R)-lipoic acid.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11908
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
21.54M21.55M21.56M21.57M21.58M21.59M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions