Gene

Fhit

Species
Rattus norvegicus
Symbol
Fhit
Name
fragile histidine triad diadenosine triphosphatase
Synonyms
  • adenosine 5'-monophosphoramidase FHIT
  • adenylylsulfatase
Biotype
protein coding gene
Automated Description
Enables bis(5'-adenosyl)-triphosphatase activity and nickel cation binding activity. Involved in diadenosine triphosphate catabolic process. Predicted to be located in cytosol and fibrillar center. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Used to study hepatocellular carcinoma. Human ortholog(s) of this gene implicated in carcinoma (multiple); invasive ductal carcinoma; reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to human FHIT (fragile histidine triad diadenosine triphosphatase).
RGD Description
Enables bis(5'-adenosyl)-triphosphatase activity and nickel cation binding activity. Involved in diadenosine triphosphate catabolic process. Predicted to be located in cytosol and fibrillar center. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Used to study hepatocellular carcinoma. Human ortholog(s) of this gene implicated in carcinoma (multiple); invasive ductal carcinoma; reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to human FHIT (fragile histidine triad diadenosine triphosphatase); PARTICIPATES IN non-small cell lung carcinoma pathway; purine metabolic pathway; small cell lung carcinoma pathway; INTERACTS WITH 1-nitropropane; 2,4-diaminotoluene; 2,6-diaminotoluene.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR46981
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
14.0M14.2M14.4M14.6M14.8M15.0M15.2M15.4M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions