Gene

Ltbp3

Species
Rattus norvegicus
Symbol
Ltbp3
Name
latent transforming growth factor beta binding protein 3
Synonyms
  • hypothetical protein LOC83838
  • latent-transforming growth factor beta-binding protein 3
Biotype
protein coding gene
Automated Description
Predicted to enable transforming growth factor beta binding activity. Predicted to be involved in positive regulation of mesenchymal stem cell differentiation and positive regulation of mesenchymal stem cell proliferation. Predicted to act upstream of or within several processes, including negative regulation of chondrocyte differentiation; positive regulation of bone resorption; and transforming growth factor beta receptor signaling pathway. Predicted to be located in collagen-containing extracellular matrix and extracellular region. Human ortholog(s) of this gene implicated in brachyolmia-amelogenesis imperfecta syndrome and geleophysic dysplasia 3. Orthologous to human LTBP3 (latent transforming growth factor beta binding protein 3).
RGD Description
Predicted to enable transforming growth factor beta binding activity. Predicted to be involved in positive regulation of mesenchymal stem cell differentiation and positive regulation of mesenchymal stem cell proliferation. Predicted to act upstream of or within several processes, including negative regulation of chondrocyte differentiation; positive regulation of bone resorption; and transforming growth factor beta receptor signaling pathway. Predicted to be located in collagen-containing extracellular matrix and extracellular region. Human ortholog(s) of this gene implicated in brachyolmia-amelogenesis imperfecta syndrome and geleophysic dysplasia 3. Orthologous to human LTBP3 (latent transforming growth factor beta binding protein 3); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24034
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            mRatBN7.2
            Viewer Help
            203.030M203.032M203.034M203.036M203.038M203.040M203.042M203.044M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Ltbp3 molecule type
            Interactor gene
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              Genetic Interactions

              Ltbp3 role
              Ltbp3 genetic perturbation
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