Version: 8.1.0Date: Fri Apr 18 2025
Gene
Cyba
- Species
- Rattus norvegicus
- Symbol
- Cyba
- Name
- cytochrome b-245 alpha chain
- Synonyms
- alpha-subunit p22
- cytochrome b-245 light chain
- Biotype
- protein coding gene
- Automated Description
- Contributes to superoxide-generating NAD(P)H oxidase activity. Involved in several processes, including cellular response to L-glutamine; cellular response to gamma radiation; and positive regulation of cell population proliferation. Located in several cellular components, including focal adhesion; perinuclear endoplasmic reticulum; and stress fiber. Part of NADPH oxidase complex. Used to study hypertension and pulmonary hypertension. Biomarker of diabetic retinopathy; end stage renal disease; hypertension; and myocardial infarction. Human ortholog(s) of this gene implicated in artery disease (multiple); asthma; chronic obstructive pulmonary disease; and phagocyte bactericidal dysfunction (multiple). Orthologous to human CYBA (cytochrome b-245 alpha chain).
- RGD Description
- Contributes to superoxide-generating NAD(P)H oxidase activity. Involved in several processes, including cellular response to L-glutamine; cellular response to gamma radiation; and positive regulation of cell population proliferation. Located in several cellular components, including focal adhesion; perinuclear endoplasmic reticulum; and stress fiber. Part of NADPH oxidase complex. Used to study hypertension and pulmonary hypertension. Biomarker of diabetic retinopathy; end stage renal disease; hypertension; and myocardial infarction. Human ortholog(s) of this gene implicated in artery disease (multiple); asthma; chronic obstructive pulmonary disease; and phagocyte bactericidal dysfunction (multiple). Orthologous to human CYBA (cytochrome b-245 alpha chain); PARTICIPATES IN thyroid hormone biosynthetic pathway; Leishmaniasis pathway; phagocytosis pathway; INTERACTS WITH (R)-lipoic acid; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,2-dimethylhydrazine.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR15168
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr19:50487597...50495721 - (8.12 kb)
- Assembly version
- mRatBN7.2
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.