Gene

Cybb

Species
Rattus norvegicus
Symbol
Cybb
Name
cytochrome b-245 beta chain
Synonyms
  • cytochrome b-245, beta polypeptide
  • endothelial type gp91-phox
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including heme binding activity; protein heterodimerization activity; and superoxide-generating NADPH oxidase activity. Predicted to contribute to electron transfer activity. Involved in several processes, including cellular response to L-glutamine; cellular response to ethanol; and hypoxia-inducible factor-1alpha signaling pathway. Located in several cellular components, including neuronal cell body; nuclear envelope; and perinuclear endoplasmic reticulum. Part of NADPH oxidase complex. Biomarker of artery disease (multiple); end stage renal disease; primary hyperaldosteronism; and renal fibrosis. Human ortholog(s) of this gene implicated in X-linked chronic granulomatous disease; chronic granulomatous disease; and immunodeficiency 34. Orthologous to human CYBB (cytochrome b-245 beta chain).
RGD Description
Predicted to enable several functions, including flavin adenine dinucleotide binding activity; heme binding activity; and protein heterodimerization activity. Predicted to contribute to electron transfer activity. Involved in several processes, including cellular response to L-glutamine; cellular response to ethanol; and hypoxia-inducible factor-1alpha signaling pathway. Located in several cellular components, including neuronal cell body; nuclear envelope; and perinuclear endoplasmic reticulum. Part of NADPH oxidase complex. Biomarker of artery disease (multiple); end stage renal disease; primary hyperaldosteronism; and renal fibrosis. Human ortholog(s) of this gene implicated in X-linked chronic granulomatous disease; chronic granulomatous disease; and immunodeficiency 34. Orthologous to human CYBB (cytochrome b-245 beta chain); PARTICIPATES IN thyroid hormone biosynthetic pathway; phagocytosis pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; (R)-carnitine; (R)-lipoic acid.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11972
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
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13.360M13.365M13.370M13.375M13.380M13.385M13.390M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions