Predicted to enable several functions, including heme binding activity; protein heterodimerization activity; and superoxide-generating NADPH oxidase activity. Predicted to contribute to electron transfer activity. Involved in several processes, including cellular response to L-glutamine; cellular response to ethanol; and hypoxia-inducible factor-1alpha signaling pathway. Located in several cellular components, including neuronal cell body; nuclear envelope; and perinuclear endoplasmic reticulum. Part of NADPH oxidase complex. Biomarker of artery disease (multiple); end stage renal disease; primary hyperaldosteronism; and renal fibrosis. Human ortholog(s) of this gene implicated in X-linked chronic granulomatous disease; chronic granulomatous disease; and immunodeficiency 34. Orthologous to human CYBB (cytochrome b-245 beta chain).
RGD Description
Predicted to enable several functions, including flavin adenine dinucleotide binding activity; heme binding activity; and protein heterodimerization activity. Predicted to contribute to electron transfer activity. Involved in several processes, including cellular response to L-glutamine; cellular response to ethanol; and hypoxia-inducible factor-1alpha signaling pathway. Located in several cellular components, including neuronal cell body; nuclear envelope; and perinuclear endoplasmic reticulum. Part of NADPH oxidase complex. Biomarker of artery disease (multiple); end stage renal disease; primary hyperaldosteronism; and renal fibrosis. Human ortholog(s) of this gene implicated in X-linked chronic granulomatous disease; chronic granulomatous disease; and immunodeficiency 34. Orthologous to human CYBB (cytochrome b-245 beta chain); PARTICIPATES IN thyroid hormone biosynthetic pathway; phagocytosis pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; (R)-carnitine; (R)-lipoic acid.