Version: 8.0.0
Date: Tue Jan 28 2025
Cd14
Rattus norvegicusRGD:620588
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Cd14

Species
Rattus norvegicus
Symbol
Cd14
Name
CD14 molecule
Synonyms
  • CD14 antigen
  • monocyte differentiation antigen CD14
Biotype
protein coding gene
Automated Description
Predicted to enable lipopolysaccharide binding activity; lipopolysaccharide immune receptor activity; and lipoteichoic acid binding activity. Involved in several processes, including cellular response to lipopolysaccharide; response to magnesium ion; and response to tumor necrosis factor. Located in cell surface and extracellular space. Used to study perinatal necrotizing enterocolitis. Biomarker of Hirschsprung's disease; cholestasis; metabolic dysfunction and alcohol associated liver disease; obstructive jaundice; and periodontitis. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; artery disease (multiple); celiac disease; cystic fibrosis; and pulmonary tuberculosis. Orthologous to human CD14 (CD14 molecule).
RGD Description
Predicted to enable lipopolysaccharide binding activity; lipopolysaccharide immune receptor activity; and lipoteichoic acid binding activity. Involved in several processes, including cellular response to lipopolysaccharide; response to magnesium ion; and response to tumor necrosis factor. Located in cell surface and extracellular space. Used to study perinatal necrotizing enterocolitis. Biomarker of Hirschsprung's disease; cholestasis; obstructive jaundice; and periodontitis. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; artery disease (multiple); celiac disease; cystic fibrosis; and pulmonary tuberculosis. Orthologous to human CD14 (CD14 molecule); PARTICIPATES IN cardiovascular system disease pathway; innate immune response pathway; Toll-like receptor signaling pathway; INTERACTS WITH (S)-colchicine; 17alpha-ethynylestradiol; 17beta-estradiol.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10630
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Cd14 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Cd14 role
            Cd14 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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