Version: 8.0.0
Date: Tue Jan 28 2025
Cyp2d4
Rattus norvegicusRGD:620640
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Cyp2d4

Species
Rattus norvegicus
Symbol
Cyp2d4
Name
cytochrome P450, family 2, subfamily d, polypeptide 4
Synonyms
  • Cyp2d18
  • Cyp2d22
Biotype
protein coding gene
Automated Description
Enables arachidonate monooxygenase activity and progesterone 21-hydroxylase activity. Involved in several processes, including arachidonate metabolic process; phenol-containing compound biosynthetic process; and response to toluene. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Biomarker of traumatic brain injury. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hepatitis; extrapyramidal and movement disease; head and neck squamous cell carcinoma; leukemia (multiple); and major depressive disorder. Orthologous to several human genes including CYP2D6 (cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene)).
RGD Description
Enables arachidonate monooxygenase activity and progesterone 21-hydroxylase activity. Involved in several processes, including carboxylic acid metabolic process; dopamine biosynthetic process; and response to toluene. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Biomarker of traumatic brain injury. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hepatitis; extrapyramidal and movement disease; head and neck squamous cell carcinoma; leukemia (multiple); and major depressive disorder. Orthologous to several human genes including CYP2D6 (cytochrome P450 family 2 subfamily D member 6); PARTICIPATES IN celecoxib pharmacodynamics pathway; celecoxib pharmacokinetics pathway; citalopram pharmacodynamics pathway; INTERACTS WITH (S)-duloxetine hydrochloride; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24300
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Download all Alleles/Variants for all genes of the species

        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
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            Sequence Feature Viewer

            Genome location
            Assembly version
            mRatBN7.2
            Viewer Help
            113.882M113.883M113.884M113.885M113.886M113.887M113.888M113.889M113.890M113.891M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Cyp2d4 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              Cyp2d4 role
              Cyp2d4 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
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