Version: 8.0.0
Date: Tue Jan 28 2025
Ptprq
Rattus norvegicusRGD:620779
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Ptprq

Species
Rattus norvegicus
Symbol
Ptprq
Name
protein tyrosine phosphatase, receptor type, Q
Synonyms
  • glomerular mesangial cell receptor protein-tyrosine phosphatase
  • glomerular mesangial cell receptor protein-tyrosine phosphatase precursor
Biotype
protein coding gene
Automated Description
Predicted to enable phosphatase activity. Predicted to be involved in detection of mechanical stimulus involved in sensory perception of sound and regulation of fat cell differentiation. Predicted to act upstream of or within hematopoietic progenitor cell differentiation; neuromuscular process controlling balance; and vestibular receptor cell morphogenesis. Predicted to be located in apical plasma membrane and stereocilium base. Predicted to be part of receptor complex. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 73 and autosomal recessive nonsyndromic deafness 84A. Orthologous to human PTPRQ (protein tyrosine phosphatase receptor type Q).
RGD Description
Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in detection of mechanical stimulus involved in sensory perception of sound and regulation of fat cell differentiation. Predicted to act upstream of or within hematopoietic progenitor cell differentiation; neuromuscular process controlling balance; and vestibular receptor cell morphogenesis. Predicted to be located in apical plasma membrane and stereocilium base. Predicted to be part of receptor complex. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 73 and autosomal recessive nonsyndromic deafness 84A. Orthologous to human PTPRQ (protein tyrosine phosphatase receptor type Q); PARTICIPATES IN auditory mechanotransduction pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 6-propyl-2-thiouracil; acrylamide.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR46957
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Ptprq molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Ptprq role
            Ptprq genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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