Version: 8.0.0
Date: Tue Jan 28 2025
Src
Rattus norvegicusRGD:620795
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Src

Species
Rattus norvegicus
Symbol
Src
Name
SRC proto-oncogene, non-receptor tyrosine kinase
Synonyms
  • c-Src
  • p60-Src
Biotype
protein coding gene
Automated Description
Enables several functions, including insulin receptor binding activity; nuclear estrogen receptor binding activity; and protein kinase C binding activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; cellular response to peptide hormone stimulus; and positive regulation of signal transduction. Located in several cellular components, including caveola; dendrite; and synaptic membrane. Is active in glutamatergic synapse and postsynaptic specialization, intracellular component. Used to study Parkinsonism; brain ischemia; hypertension; status epilepticus; and type 2 diabetes mellitus. Biomarker of hepatocellular carcinoma and pancreatic acinar cell adenocarcinoma. Human ortholog(s) of this gene implicated in colorectal cancer (multiple); ductal carcinoma in situ; prostate cancer; thrombocytopenia; and type 2 diabetes mellitus. Orthologous to human SRC (SRC proto-oncogene, non-receptor tyrosine kinase).
RGD Description
Enables several functions, including insulin receptor binding activity; nuclear estrogen receptor binding activity; and protein kinase C binding activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; cellular response to peptide hormone stimulus; and positive regulation of signal transduction. Located in several cellular components, including caveola; dendrite; and synaptic membrane. Is active in glutamatergic synapse and postsynaptic specialization, intracellular component. Used to study Parkinsonism; brain ischemia; hypertension; status epilepticus; and type 2 diabetes mellitus. Biomarker of hepatocellular carcinoma and pancreatic acinar cell adenocarcinoma. Human ortholog(s) of this gene implicated in colorectal cancer (multiple); ductal carcinoma in situ; prostate cancer; thrombocytopenia; and type 2 diabetes mellitus. Orthologous to human SRC (SRC proto-oncogene, non-receptor tyrosine kinase); PARTICIPATES IN dopamine signaling pathway; epidermal growth factor/neuregulin signaling pathway; estrogen signaling pathway; INTERACTS WITH (+)-pilocarpine; (25R)-cholest-5-ene-3beta,26-diol; 1,2,3,4,6,7,8-Heptachlorodibenzodioxin.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR46037
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Src molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Src role
            Src genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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