Version: 8.0.0Date: Tue Jan 28 2025
Gene
Aifm1
- Species
- Rattus norvegicus
- Symbol
- Aifm1
- Name
- apoptosis inducing factor, mitochondria associated 1
- Synonyms
- Aif
- apoptosis-inducing factor 1, mitochondrial
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable several functions, including FAD binding activity; NAD(P)H oxidase H2O2-forming activity; and poly-ADP-D-ribose binding activity. Involved in several processes, including cellular response to aldosterone; cellular response to estradiol stimulus; and cellular response to nitric oxide. Predicted to be located in cytosol and mitochondrial intermembrane space. Predicted to be active in mitochondrion and nucleus. Biomarker of middle cerebral artery infarction; retinal detachment; retinitis pigmentosa; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease X-linked recessive 4; X-linked deafness 5; and combined oxidative phosphorylation deficiency 6. Orthologous to human AIFM1 (apoptosis inducing factor mitochondria associated 1).
- RGD Description
- Predicted to enable several functions, including FAD binding activity; NAD(P)H oxidase H2O2-forming activity; and poly-ADP-D-ribose binding activity. Involved in several processes, including cellular response to aldosterone; cellular response to estradiol stimulus; and cellular response to nitric oxide. Predicted to be located in cytosol and mitochondrial intermembrane space. Predicted to be active in mitochondrion and nucleus. Biomarker of middle cerebral artery infarction; retinal detachment; retinitis pigmentosa; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease X-linked recessive 4; X-linked deafness 5; and combined oxidative phosphorylation deficiency 6. Orthologous to human AIFM1 (apoptosis inducing factor mitochondria associated 1); PARTICIPATES IN ceramide signaling pathway; apoptotic cell death pathway; INTERACTS WITH (+)-schisandrin B; (+)-sesamin; (Z)-3-butylidenephthalide.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR43557
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- None
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- ChrX:127650223...127689356 - (39.13 kb)
- Assembly version
- mRatBN7.2
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.