Gene

Pik3cb

Species
Rattus norvegicus
Symbol
Pik3cb
Name
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
Synonyms
  • catalytic phosphatidylinositol 3-kinase beta
  • LOC100910021
Biotype
protein coding gene
Automated Description
Enables 1-phosphatidylinositol-3-kinase activity. Involved in phosphatidylinositol phosphate biosynthetic process. Located in brush border membrane. Part of phosphatidylinositol 3-kinase complex. Used to study thrombosis. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in glioblastoma; prostate adenocarcinoma; prostate cancer; and type 2 diabetes mellitus. Orthologous to human PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta).
RGD Description
Enables 1-phosphatidylinositol-3-kinase activity. Involved in phosphatidylinositol phosphate biosynthetic process. Located in brush border membrane. Part of phosphatidylinositol 3-kinase complex. Used to study thrombosis. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in glioblastoma; prostate adenocarcinoma; prostate cancer; and type 2 diabetes mellitus. Orthologous to human PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; FasL mediated signaling pathway; phosphatidylinositol 3-kinase class I signaling pathway; INTERACTS WITH 17beta-estradiol; 2,6-dinitrotoluene; allethrin.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10048
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
99.60M99.61M99.62M99.63M99.64M99.65M99.66M99.67M99.68M99.69M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions