Gene

Eif2s1

Species
Rattus norvegicus
Symbol
Eif2s1
Name
eukaryotic translation initiation factor 2 subunit alpha
Synonyms
  • eIF-2-alpha
  • EIF-2A
Biotype
protein coding gene
Automated Description
Predicted to enable ribosome binding activity and translation initiation factor activity. Involved in several processes, including negative regulation of guanyl-nucleotide exchange factor activity; positive regulation of type B pancreatic cell apoptotic process; and response to manganese-induced endoplasmic reticulum stress. Located in glial limiting end-foot. Part of eukaryotic translation initiation factor 2 complex and translation initiation ternary complex. Used to study middle cerebral artery infarction. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha).
RGD Description
Predicted to enable ribosome binding activity and translation initiation factor activity. Involved in several processes, including negative regulation of guanyl-nucleotide exchange factor activity; positive regulation of type B pancreatic cell apoptotic process; and response to manganese-induced endoplasmic reticulum stress. Located in glial limiting end-foot. Part of eukaryotic translation initiation factor 2 complex and translation initiation ternary complex. Used to study middle cerebral artery infarction. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha); PARTICIPATES IN translation initiation pathway; Endoplasmic Reticulum-associated degradation pathway; hepatitis C pathway; INTERACTS WITH (+)-schisandrin B; (R)-lipoic acid; (S)-nicotine.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10602
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            mRatBN7.2
            Viewer Help
            97.675M97.680M97.685M97.690M97.695M97.700M97.705M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Eif2s1 molecule type
            Interactor gene
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              Genetic Interactions

              Eif2s1 role
              Eif2s1 genetic perturbation
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