Enables several functions, including DNA (cytosine-5-)-methyltransferase activity; histone deacetylase binding activity; and nuclear estrogen receptor binding activity. Involved in several processes, including cellular response to lead ion; cellular response to platelet-derived growth factor stimulus; and negative regulation of gene expression via chromosomal CpG island methylation. Located in nucleus. Part of protein-containing complex. Used to study choline deficiency disease and lung carcinoma. Biomarker of several diseases, including choline deficiency disease; congestive heart failure; fetal alcohol spectrum disorder; liver disease (multiple); and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Graves' disease; autosomal dominant cerebellar ataxia, deafness and narcolepsy; hereditary sensory neuropathy; hereditary sensory neuropathy type 1E; and lung non-small cell carcinoma. Orthologous to human DNMT1 (DNA methyltransferase 1).
RGD Description
Enables several functions, including DNA (cytosine-5-)-methyltransferase activity; histone deacetylase binding activity; and nuclear estrogen receptor binding activity. Involved in several processes, including cellular response to lead ion; cellular response to platelet-derived growth factor stimulus; and negative regulation of gene expression via chromosomal CpG island methylation. Located in nucleus. Part of protein-containing complex. Used to study choline deficiency disease and lung carcinoma. Biomarker of several diseases, including choline deficiency disease; congestive heart failure; fetal alcohol spectrum disorder; liver disease (multiple); and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Graves' disease; autosomal dominant cerebellar ataxia, deafness and narcolepsy; hereditary sensory neuropathy; hereditary sensory neuropathy type 1E; and lung non-small cell carcinoma. Orthologous to human DNMT1 (DNA methyltransferase 1); PARTICIPATES IN DNA modification pathway; glycine N-methyltransferase deficiency pathway; homocystinuria pathway; INTERACTS WITH (S)-nicotine; 1,2-dimethylhydrazine; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile.