Version: 8.0.0
Date: Tue Jan 28 2025
P4ha1
Rattus norvegicusRGD:621000
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

P4ha1

Species
Rattus norvegicus
Symbol
P4ha1
Name
prolyl 4-hydroxylase subunit alpha 1
Synonyms
  • 4-PH alpha-1
  • PHalphaI
Biotype
protein coding gene
Automated Description
Predicted to enable identical protein binding activity and procollagen-proline 4-dioxygenase activity. Predicted to be involved in collagen fibril organization. Predicted to act upstream of or within peptidyl-proline hydroxylation to 4-hydroxy-L-proline. Predicted to be located in mitochondrion. Predicted to be part of procollagen-proline 4-dioxygenase complex. Predicted to be active in endoplasmic reticulum. Orthologous to human P4HA1 (prolyl 4-hydroxylase subunit alpha 1).
RGD Description
Predicted to enable identical protein binding activity and procollagen-proline 4-dioxygenase activity. Predicted to be involved in collagen fibril organization. Predicted to act upstream of or within peptidyl-proline hydroxylation to 4-hydroxy-L-proline. Predicted to be located in mitochondrion. Predicted to be part of procollagen-proline 4-dioxygenase complex. Predicted to be active in endoplasmic reticulum. Orthologous to human P4HA1 (prolyl 4-hydroxylase subunit alpha 1); PARTICIPATES IN arginine and proline metabolic pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10869
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensP4HA110 of 10YesYes☑☑☑☑☑☑☑☑☑☑  
Mus musculusP4ha19 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Xenopus tropicalisp4ha15 of 9YesYes☑ ☐☐☑☑☐☑☑☐  
Danio reriop4ha1b8 of 9YesYes☑ ☐☑☑☑☑☑☑☑  
Danio reriop4ha1a6 of 9NoYes☐ ☑☐☑☑☑☑☑☐  
Drosophila melanogasterPH4αEFB9 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Caenorhabditis elegansphy-29 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Caenorhabditis elegansdpy-187 of 9NoYes☐ ☑☑☑☑☑☑☐☑  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
P4ha2151780647 of 9☑☐☑☐☑☑☑☑☑ 
P4ha3253353346 of 9☑☐☐☐☑☑☑☑☑ 
P4htm341635253 of 9☑☐☐☐☐☐☑☑☐ 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
No records match query. Try removing filters.
Showing 0 - 0 of 0 rows
per page

    Alleles and Variants

    Genome location
    Assembly version
    mRatBN7.2
    Viewer Help
    Data currently unavailable; sequence viewer under construction
    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
    NC_051355.1:g.27306646A>Gvariant
    SNP
    • intron variant
    NC_051355.1:g.27309993A>Gvariant
    SNP
    • intron variant
    NC_051355.1:g.27311600G>Avariant
    SNP
    • intron variant
    NC_051355.1:g.27318320T>Cvariant
    SNP
    • intron variant
    NC_051355.1:g.27320487G>Cvariant
    SNP
    • intron variant
    NC_051355.1:g.27320810T>Cvariant
    SNP
    • intron variant
    NC_051355.1:g.27342063T>Cvariant
    SNP
    • intron variant
    NC_051355.1:g.27350449T>Cvariant
    SNP
    • intron variant
    NC_051355.1:g.27351812A>Tvariant
    SNP
    • 3 prime UTR variant
    NC_051355.1:g.27323192A>Tvariant
    SNP
    • intron variant
    Showing 1 - 10 of 126 rows
    per page
    View detailed Alleles/Variants information
    Download all Alleles/Variants for all genes of the species

    Transgenic Alleles

    No data available

    Models

    No data available

    Sequence Feature Viewer

    Genome location
    Assembly version
    mRatBN7.2
    Viewer Help
    Data currently unavailable; sequence viewer under construction

    Sequence Details

    Loading...

    Expression

    Primary Sources
    None
    Other Sources
    Must provide at least one subject
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    1 interactor gene based on 1 annotation
    P4ha1 molecule type
    Interactor gene
    Interactor species
    Interactor molecule type
    Detection methods
    Source
    Reference
    protein
    		Fbxo21Rattus norvegicus
    protein
    • affinity chromatography technology
    		PMID:33450132
    Showing 1 - 1 of 1 rows
    per page

    Genetic Interactions

    No data available