Gene

Cdk6

Species
Rattus norvegicus
Symbol
Cdk6
Name
cyclin-dependent kinase 6
Synonyms
  • cell division protein kinase 6
Biotype
protein coding gene
Automated Description
Enables cyclin binding activity. Involved in DNA damage response. Predicted to be located in several cellular components, including centrosome; nucleoplasm; and ruffle. Predicted to be part of cyclin D1-CDK6 complex; cyclin D2-CDK6 complex; and cyclin D3-CDK6 complex. Predicted to be active in cytoplasm and nucleus. Biomarker of interstitial cystitis. Human ortholog(s) of this gene implicated in high grade glioma; lung non-small cell carcinoma; pancreatic adenocarcinoma; pancreatic ductal carcinoma; and primary autosomal recessive microcephaly 12. Orthologous to human CDK6 (cyclin dependent kinase 6).
RGD Description
Enables cyclin binding activity. Involved in DNA damage response. Predicted to be located in several cellular components, including centrosome; nucleoplasm; and ruffle. Predicted to be part of cyclin D1-CDK6 complex; cyclin D2-CDK6 complex; and cyclin D3-CDK6 complex. Predicted to be active in cytoplasm and nucleus. Biomarker of interstitial cystitis. Human ortholog(s) of this gene implicated in high grade glioma; lung non-small cell carcinoma; pancreatic adenocarcinoma; pancreatic ductal carcinoma; and primary autosomal recessive microcephaly 12. Orthologous to human CDK6 (cyclin dependent kinase 6); PARTICIPATES IN G1/S transition pathway; cell cycle pathway, mitotic; ceramide signaling pathway; INTERACTS WITH (Z)-3-butylidenephthalide; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24056
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensCDK610 of 10YesYes  
Mus musculusCdk69 of 9YesYes   
Xenopus tropicaliscdk65 of 9YesYes   
Danio reriocdk69 of 9YesYes   
Drosophila melanogasterCdk48 of 9YesYes   
Caenorhabditis eleganscdk-45 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Cdk4122883707 of 9 
Cdk2234756413 of 9 
Cdk1330066463 of 9 
Cdk5429762463 of 9 
Cdk14530562433 of 9 
Cdk11b630263403 of 9 
Cdk12732856383 of 9 
Cdk18830357443 of 9 
Cdk19933156373 of 9 
Cdk91032956373 of 9 
Cdkl11134753343 of 9 
Cdk161230059423 of 9 
Cdkl31333456343 of 9 
Cdk101433753363 of 9 
Cdk171530059413 of 9 
Cdkl51632955363 of 9 
Cdk71730957393 of 9 
Cdk131832256392 of 9 
Cdk151930659412 of 9 
Cdkl22033252343 of 9 
Cdk202129557393 of 9 
Cdkl42230559362 of 9 
Prpf4b2333346282 of 9 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
Rattus norvegicusCdk6
is marker forinterstitial cystitis
  • IEP
    Homo sapiensCDK6
    is marker for
    • severity of
    glioblastoma
    • IEP
      Homo sapiensCDK6
      is implicated inhigh grade glioma
      • IAGP
        Homo sapiensCDK6
        is marker for
        • severity of
        high grade glioma
        • IEP
          Homo sapiensCDK6
          is marker forlung adenocarcinoma
          • IEP
            Homo sapiensCDK6
            is marker forlung non-small cell carcinoma
            • IEP
              Homo sapiensCDK6
              is implicated inlung non-small cell carcinoma
              • IDA
                Homo sapiensCDK6
                is marker for
                • disease progression of
                medulloblastoma
                • IEP
                  Homo sapiensCDK6
                  is marker fornon-functioning pancreatic endocrine tumor
                  • IEP
                    Homo sapiensCDK6
                    is implicated inpancreatic adenocarcinoma
                    • IDA
                      Showing 1 - 10 of 13 rows
                      per page

                      Alleles and Variants

                      Genome location
                      Assembly version
                      mRatBN7.2
                      Viewer Help
                      30.64M30.66M30.68M30.70M30.72M30.74M30.76M30.78M30.80M30.82M
                      Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
                      Allele/Variant Symbol
                      Allele Synonyms
                      Category
                      Variant
                      Variant type
                      Molecular consequence
                      Has Disease Annotations
                      Has Phenotype Annotations
                      NC_051339.1:g.30786785G>Avariant
                      SNP
                      • intron variant
                      NC_051339.1:g.30797506G>Avariant
                      SNP
                      • intron variant
                      NC_051339.1:g.30782131T>Avariant
                      SNP
                      • intron variant
                      NC_051339.1:g.30645112A>Tvariant
                      SNP
                      • non coding transcript exon variant
                      NC_051339.1:g.30647247G>Tvariant
                      SNP
                      • intron variant
                      NC_051339.1:g.30727443C>Tvariant
                      SNP
                      • intron variant
                      NC_051339.1:g.30754320A>Cvariant
                      SNP
                      • intron variant
                      NC_051339.1:g.30784425A>Cvariant
                      SNP
                      • intron variant
                      NC_051339.1:g.30645459C>Tvariant
                      SNP
                      • non coding transcript exon variant
                      NC_051339.1:g.30645987C>Tvariant
                      SNP
                      • 3 prime UTR variant
                      Showing 1 - 10 of 101 rows
                      per page

                      Transgenic Alleles

                      No data available

                      Models

                      No data available

                      Sequence Feature Viewer

                      Genome location
                      Assembly version
                      mRatBN7.2
                      Viewer Help
                      30.64M30.66M30.68M30.70M30.72M30.74M30.76M30.78M30.80M30.82MENSRNOT00000012597.7 (Cdk6)ENSRNOT00000104799.1 (Cdk6)NM_001191861.2 (Cdk6)XM_006236019.5 (Cdk6)XM_006236020.5 (Cdk6)XM_006236021.4 (Cdk6)XM_039106910.2 (Cdk6)ENSRNOT00000098641.1 (ENSRNOG00000063932)

                      Sequence Details

                      Loading...

                      Expression

                      Primary Sources
                      None
                      Other Sources
                      Must provide at least one subject
                      Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

                      Molecular Interactions

                      No data available

                      Genetic Interactions

                      No data available