Gene

Hand1

Species
Rattus norvegicus
Symbol
Hand1
Name
heart and neural crest derivatives expressed 1
Synonyms
  • eHand
  • extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding activity; and protein homodimerization activity. Predicted to contribute to transcription cis-regulatory region binding activity. Predicted to be involved in cardiac chamber morphogenesis; in utero embryonic development; and regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including cartilage morphogenesis; circulatory system development; and regulation of DNA-templated transcription. Located in nucleus. Orthologous to human HAND1 (heart and neural crest derivatives expressed 1).
RGD Description
Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding activity; and protein homodimerization activity. Predicted to contribute to transcription cis-regulatory region binding activity. Predicted to be involved in cardiac chamber morphogenesis; in utero embryonic development; and regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including cartilage morphogenesis; circulatory system development; and regulation of DNA-templated transcription. Located in nucleus. Orthologous to human HAND1 (heart and neural crest derivatives expressed 1); INTERACTS WITH (S)-nicotine; 2,2',4,4'-Tetrabromodiphenyl ether; all-trans-retinoic acid.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23349
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensHAND110 of 10YesYes  
Mus musculusHand19 of 9YesYes   
Xenopus tropicalishand18 of 9YesYes   
Drosophila melanogasterHand6 of 9YesNo   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Hand2122864556 of 9 
Ptf1a224039313 of 9 
Twist1318340313 of 9 
Scx415547373 of 9 
Tcf15514452383 of 9 
Msc615546353 of 9 
Tcf24711953423 of 9 
Figla814743313 of 9 
Tcf21912644343 of 9 
Twist2109153403 of 9 
Bhlha91117033252 of 9 
Tcf23128056403 of 9 
Ferd3l137662373 of 9 

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
mRatBN7.2
Viewer Help
42.0070M42.0075M42.0080M42.0085M42.0090M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
Hand1m1Mcwi
  • Hand1m1Mcwi
allele
NC_051345.1:g.42008887C>Gvariant
SNP
  • synonymous variant
NC_051345.1:g.42009083T>Avariant
SNP
  • 5 prime UTR variant
NC_051345.1:g.42007016T>Cvariant
SNP
  • intron variant
NC_051345.1:g.42007979A>Cvariant
SNP
  • intron variant
Showing 1 - 5 of 5 rows
per page

Transgenic Alleles

No data available

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
BN-Hand1m1McwiRGD
Showing 1 - 1 of 1 rows
per page

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
42.0070M42.0075M42.0080M42.0085M42.0090MENSRNOT00000003486.6 (Hand1)NM_021592.2 (Hand1)

Sequence Details

Transcript: Mode:

Expression

Primary Sources
None
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

No data available

Genetic Interactions

No data available