Version: 8.1.0Date: Fri Apr 18 2025
Gene
Nrg1
- Species
- Rattus norvegicus
- Symbol
- Nrg1
- Name
- neuregulin 1
- Synonyms
- glial growth factor
- neuregulin 1 type III beta 3
- Biotype
- protein coding gene
- Automated Description
- Enables receptor tyrosine kinase binding activity. Involved in several processes, including cardiac muscle cell apoptotic process; cellular response to L-glutamate; and positive regulation of cell population proliferation. Located in several cellular components, including dendrite; extracellular space; and neuronal cell body. Used to study Alzheimer's disease and sciatic neuropathy. Biomarker of several diseases, including amblyopia; epilepsy (multiple); interstitial cystitis; neuropathy (multiple); and overactive bladder syndrome. Human ortholog(s) of this gene implicated in several diseases, including cannabis dependence; cerebral malaria; cerebrovascular disease (multiple); psychotic disorder (multiple); and substance abuse (multiple). Orthologous to human NRG1 (neuregulin 1).
- RGD Description
- Enables receptor tyrosine kinase binding activity. Involved in several processes, including cardiac muscle cell apoptotic process; cellular response to L-glutamate; and positive regulation of cell population proliferation. Located in several cellular components, including dendrite; extracellular space; and neuronal cell body. Used to study Alzheimer's disease and sciatic neuropathy. Biomarker of several diseases, including amblyopia; epilepsy (multiple); interstitial cystitis; neuropathy (multiple); and overactive bladder syndrome. Human ortholog(s) of this gene implicated in several diseases, including cannabis dependence; cerebral malaria; cerebrovascular disease (multiple); psychotic disorder (multiple); and substance abuse (multiple). Orthologous to human NRG1 (neuregulin 1); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; glypican signaling pathway; INTERACTS WITH (+)-schisandrin B; 1-benzylpiperazine; 1-naphthyl isothiocyanate.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR11100
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr16:59250658...60304519 + (1,053.86 kb)
- Assembly version
- mRatBN7.2
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.