Version: 8.0.0
Date: Tue Jan 28 2025
Wnt2
Rattus norvegicusRGD:621346
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Wnt2

Species
Rattus norvegicus
Symbol
Wnt2
Name
Wnt family member 2
Synonyms
  • protein Wnt-2
  • wingless-related MMTV integration site 2
Biotype
protein coding gene
Automated Description
Predicted to enable cytokine activity and frizzled binding activity. Involved in lung development and positive regulation of endothelial cell proliferation. Predicted to be located in collagen-containing extracellular matrix; cytoplasm; and extracellular region. Biomarker of visual epilepsy. Human ortholog(s) of this gene implicated in breast carcinoma; hepatocellular carcinoma; and urinary system cancer. Orthologous to human WNT2 (Wnt family member 2).
RGD Description
Predicted to enable cytokine activity and frizzled binding activity. Involved in lung development and positive regulation of endothelial cell proliferation. Predicted to be located in collagen-containing extracellular matrix; cytoplasm; and extracellular region. Predicted to be active in extracellular space. Biomarker of visual epilepsy. Human ortholog(s) of this gene implicated in breast carcinoma; hepatocellular carcinoma; and urinary system cancer. Orthologous to human WNT2 (Wnt family member 2); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; basal cell carcinoma pathway; INTERACTS WITH 1,3-dinitrobenzene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12027
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensWNT210 of 10YesYes☑☑☑☑☑☑☑☑☑☑  
Mus musculusWnt29 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Xenopus tropicaliswnt29 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Danio reriownt24 of 9YesYes☑ ☐☐☐☑☐☑☑☐  
Caenorhabditis eleganscwn-13 of 9YesNo☑ ☐☑☐☐☐☐☐☑  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Wnt2b135682706 of 9☑☐☑☐☐☑☑☑☑ 
Wnt5b237861476 of 9☑☐☑☐☐☑☑☑☑ 
Wnt4334666486 of 9☑☐☑☐☐☑☑☑☑ 
Wnt5a434263506 of 9☑☐☑☐☐☑☑☑☑ 
Wnt7a536459456 of 9☑☐☑☐☐☑☑☑☑ 
Wnt7b631966506 of 9☑☐☑☐☐☑☑☑☑ 
Wnt3a734564436 of 9☑☐☑☐☐☑☑☑☑ 
Wnt16836359426 of 9☑☐☑☐☐☑☑☑☑ 
Wnt1938057413 of 9☑☐☐☐☐☐☑☑☐ 
Wnt31031460446 of 9☑☐☑☐☐☑☑☑☑ 
Wnt10b1139154393 of 9☑☐☐☐☐☐☑☑☐ 
Wnt61236455403 of 9☑☐☐☐☐☐☑☑☐ 
Wnt10a1336356393 of 9☑☐☐☐☐☐☑☑☐ 
Wnt9b1433954413 of 9☑☐☐☐☐☐☑☑☐ 
Wnt9a1538052362 of 9☑☐☐☐☐☐☐☑☐ 
Wnt8b1630860433 of 9☑☐☐☐☐☐☑☑☐ 
Wnt111732057413 of 9☑☐☐☐☐☐☑☑☐ 
Wnt8a1830757403 of 9☑☐☐☐☐☐☑☑☐ 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Must provide at least one subject
    Cell color indicative of annotation volume
    Species
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
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            Sequence Feature Viewer

            Genome location
            Assembly version
            mRatBN7.2
            Viewer Help
            Data currently unavailable; sequence viewer under construction

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Must provide at least one subject
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Wnt2 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              Wnt2 role
              Wnt2 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
              Reference
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