Version: 8.0.0Date: Tue Jan 28 2025
Gene
Ghsr
- Species
- Rattus norvegicus
- Symbol
- Ghsr
- Name
- growth hormone secretagogue receptor
- Synonyms
- GH-releasing peptide receptor
- ghrelin receptor
- Biotype
- protein coding gene
- Automated Description
- Enables growth hormone secretagogue receptor activity and peptide hormone binding activity. Involved in several processes, including cellular response to insulin-like growth factor stimulus; regulation of digestive system process; and regulation of secretion by cell. Acts upstream of or within negative regulation of insulin secretion. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and synaptic membrane. Used to study middle cerebral artery infarction. Biomarker of isolated growth hormone deficiency; multiple endocrine neoplasia; obstructive sleep apnea; status epilepticus; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in obesity. Orthologous to human GHSR (growth hormone secretagogue receptor).
- RGD Description
- Enables growth hormone secretagogue receptor activity and peptide hormone binding activity. Involved in several processes, including cellular response to insulin-like growth factor stimulus; regulation of digestive system process; and regulation of secretion by cell. Acts upstream of or within negative regulation of insulin secretion. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and synaptic membrane. Used to study middle cerebral artery infarction. Biomarker of isolated growth hormone deficiency; multiple endocrine neoplasia; obstructive sleep apnea; status epilepticus; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in obesity. Orthologous to human GHSR (growth hormone secretagogue receptor); PARTICIPATES IN G protein mediated signaling pathway via Galphaq family; ghrelin system pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,5-hexanedione; ammonium chloride.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR24243
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr2:110268489...110271865 + (3.38 kb)
- Assembly version
- mRatBN7.2
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.