Version: 8.0.0
Date: Tue Jan 28 2025
Kcnh2
Rattus norvegicusRGD:621414
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Kcnh2

Species
Rattus norvegicus
Symbol
Kcnh2
Name
potassium voltage-gated channel subfamily H member 2
Synonyms
  • eag-related protein 1
  • ERG-1
Biotype
protein coding gene
Automated Description
Enables inward rectifier potassium channel activity and scaffold protein binding activity. Involved in potassium ion transport; regulation of membrane potential; and spinal cord development. Predicted to be located in cell surface and perinuclear region of cytoplasm. Predicted to be part of inward rectifier potassium channel complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in long QT syndrome; long QT syndrome 2; and short QT syndrome. Orthologous to human KCNH2 (potassium voltage-gated channel subfamily H member 2).
RGD Description
Enables inward rectifier potassium channel activity and scaffold protein binding activity. Involved in potassium ion transport; regulation of membrane potential; and spinal cord development. Predicted to be located in cell surface and perinuclear region of cytoplasm. Predicted to be part of inward rectifier potassium channel complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in long QT syndrome; long QT syndrome 2; and short QT syndrome. Orthologous to human KCNH2 (potassium voltage-gated channel subfamily H member 2); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10217
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Kcnh2 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Kcnh2 role
            Kcnh2 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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