Version: 8.0.0
Date: Tue Jan 28 2025
Ppp1r15a
Rattus norvegicusRGD:621526
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Ppp1r15a

Species
Rattus norvegicus
Symbol
Ppp1r15a
Name
protein phosphatase 1, regulatory subunit 15A
Synonyms
  • Gadd34
  • growth arrest and DNA damage-inducible protein GADD34
Biotype
protein coding gene
Automated Description
Enables protein phosphatase 1 binding activity. Involved in several processes, including cellular response to calcium ion starvation; cellular response to cordycepin; and regulation of protein metabolic process. Predicted to be located in Golgi apparatus; membrane; and mitochondrion. Predicted to be part of protein phosphatase type 1 complex. Predicted to be active in endoplasmic reticulum. Biomarker of brain ischemia and transient cerebral ischemia. Orthologous to human PPP1R15A (protein phosphatase 1 regulatory subunit 15A).
RGD Description
Enables protein phosphatase 1 binding activity. Involved in several processes, including cellular response to calcium ion starvation; cellular response to cordycepin; and regulation of protein metabolic process. Predicted to be located in Golgi apparatus; membrane; and mitochondrion. Predicted to be part of protein phosphatase type 1 complex. Predicted to be active in endoplasmic reticulum. Biomarker of brain ischemia and transient cerebral ischemia. Orthologous to human PPP1R15A (protein phosphatase 1 regulatory subunit 15A); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (+)-schisandrin B; (S)-colchicine; 2,3,7,8-tetrachlorodibenzodioxine.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR16489
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Ppp1r15a molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Ppp1r15a role
            Ppp1r15a genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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