Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; and skeletal muscle tissue development. Predicted to act upstream of or within several processes, including in utero embryonic development; nervous system development; and regulation of cell division. Predicted to be located in heterochromatin and nuclear speck. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 22. Orthologous to human ZBTB18 (zinc finger and BTB domain containing 18).
RGD Description
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; and skeletal muscle tissue development. Predicted to act upstream of or within several processes, including in utero embryonic development; nervous system development; and regulation of cell division. Predicted to be located in heterochromatin and nuclear speck. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 22. Orthologous to human ZBTB18 (zinc finger and BTB domain containing 18); INTERACTS WITH ammonium chloride; amphetamine; bisphenol A.