Gene

Zbtb18

Species
Rattus norvegicus
Symbol
Zbtb18
Name
zinc finger and BTB domain containing 18
Synonyms
  • 58 kDa repressor protein
  • Rp58
Biotype
protein coding gene
Automated Description
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; and skeletal muscle tissue development. Predicted to act upstream of or within several processes, including in utero embryonic development; nervous system development; and regulation of cell division. Predicted to be located in heterochromatin and nuclear speck. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 22. Orthologous to human ZBTB18 (zinc finger and BTB domain containing 18).
RGD Description
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; and skeletal muscle tissue development. Predicted to act upstream of or within several processes, including in utero embryonic development; nervous system development; and regulation of cell division. Predicted to be located in heterochromatin and nuclear speck. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 22. Orthologous to human ZBTB18 (zinc finger and BTB domain containing 18); INTERACTS WITH ammonium chloride; amphetamine; bisphenol A.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24394
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
89.440M89.441M89.442M89.443M89.444M89.445M89.446M89.447M89.448M

Sequence Details

Loading...

Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions