Species

Rattus norvegicus

Symbol

P2ry12

Name

purinergic receptor P2Y12

Synonyms

P2Y purinoceptor 12
P2y12

Biotype

protein coding gene

Automated Description

Enables G protein-coupled ADP receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; monoatomic cation transmembrane transport; and positive regulation of cellular component biogenesis. Located in basal plasma membrane; caveola; and external side of plasma membrane. Used to study abdominal aortic aneurysm and thrombosis. Human ortholog(s) of this gene implicated in asthma; cerebrovascular disease; peripheral artery disease; platelet-type bleeding disorder 8; and type 2 diabetes mellitus. Orthologous to human P2RY12 (purinergic receptor P2Y12).

RGD Description

Enables G protein-coupled ADP receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; monoatomic cation transmembrane transport; and positive regulation of cellular component biogenesis. Located in basal plasma membrane; caveola; and external side of plasma membrane. Used to study abdominal aortic aneurysm and thrombosis. Human ortholog(s) of this gene implicated in asthma; cerebrovascular disease; peripheral artery disease; platelet-type bleeding disorder 8; and type 2 diabetes mellitus. Orthologous to human P2RY12 (purinergic receptor P2Y12); PARTICIPATES IN clopidogrel pharmacodynamics pathway; clopidogrel pharmacokinetics pathway; ticlopidine pharmacodynamics pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.

Cross References

Additional Information

Literature

Orthology

Gene tree: PANTHER:PTHR24233

Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse

Paralogy

Function - GO Annotations

Show functions with at least one experimental evidence

Pathways

No data available

Phenotypes

Primary Sources: None
Other Sources: None

Phenotype Term	Annotation details	References
No records match query. Try removing filters.

Showing 0 - 0 of 0 rows

per page

Disease Associations

Include negative annotationsCases where the expected disease association was NOT found

Cell color indicative of annotation volume

Alleles and Variants

Allele/Variant Symbol	Allele Synonyms	Category	Variant	Variant type	Molecular consequence	Has Disease Annotations	Has Phenotype Annotations
No records match query. Try removing filters.

Showing 0 - 0 of 0 rows

per page

Download all Alleles/Variants for all genes of the species

Transgenic Alleles

Species (carrying the transgene)	Allele symbol	Transgenic construct	Expressed components	Knock-down targets	Regulatory regions	Has Disease Annotations	Has Phenotype Annotations
No records match query. Try removing filters.

Showing 0 - 0 of 0 rows

per page

Models

Model name	Experimental condition	Associated Human Diseases	Associated Phenotypes	Modifier	Source
No records match query. Try removing filters.

Showing 0 - 0 of 0 rows

per page

Sequence Feature Viewer

Genome location

Chr2:143481430...143523361 - (41.93 kb)

Assembly version

mRatBN7.2

Viewer Help

Data currently unavailable; sequence viewer under construction

Sequence Details

Loading...

Expression

Primary Sources

None

Other Sources

Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

P2ry12 molecule type	Interactor gene	Interactor species	Interactor molecule type	Detection method	Source	Reference
No records match query. Try removing filters.

Showing 0 - 0 of 0 rows

per page

Genetic Interactions

P2ry12 role	P2ry12 genetic perturbation	Interactor gene	Interactor species	Interactor role	Interactor genetic perturbation	Interaction type	Phenotype or trait	Source	Reference
No records match query. Try removing filters.

Showing 0 - 0 of 0 rows

per page