Version: 8.0.0Date: Tue Jan 28 2025
Gene
Park7
- Species
- Rattus norvegicus
- Symbol
- Park7
- Name
- Parkinsonism associated deglycase
- Synonyms
- CAP1
- contraception-associated protein 1
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable several functions, including enzyme activator activity; enzyme binding activity; and transition metal ion binding activity. Involved in several processes, including negative regulation of NMDA glutamate receptor activity; negative regulation of vascular associated smooth muscle cell proliferation; and positive regulation of fertilization. Located in several cellular components, including endoplasmic reticulum; mitochondrion; and sperm head. Used to study Parkinson's disease and Parkinsonism. Biomarker of Parkinsonism. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 7; Parkinsonism; cerebral infarction; and middle cerebral artery infarction. Orthologous to human PARK7 (Parkinsonism associated deglycase).
- RGD Description
- Predicted to enable several functions, including enzyme activator activity; enzyme binding activity; and transition metal ion binding activity. Involved in several processes, including negative regulation of NMDA glutamate receptor activity; negative regulation of vascular associated smooth muscle cell proliferation; and positive regulation of fertilization. Located in several cellular components, including endoplasmic reticulum; mitochondrion; and sperm head. Used to study Parkinson's disease and Parkinsonism. Biomarker of Parkinsonism. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 7; Parkinsonism; cerebral infarction; and middle cerebral artery infarction. Orthologous to human PARK7 (Parkinsonism associated deglycase); PARTICIPATES IN transforming growth factor-beta signaling pathway; Parkinson's disease pathway; INTERACTS WITH 1-bromopropane; 15-deoxy-Delta(12,14)-prostaglandin J2; 2,3,7,8-tetrachlorodibenzodioxine.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR48094
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr5:161353718...161376993 - (23.28 kb)
- Assembly version
- mRatBN7.2
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.