Version: 8.0.0
Date: Tue Jan 28 2025
Gnao1
Rattus norvegicusRGD:628732
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Gnao1

Species
Rattus norvegicus
Symbol
Gnao1
Name
G protein subunit alpha o1
Synonyms
  • Gnao
  • GTP-binding protein
Biotype
protein coding gene
Automated Description
Enables several functions, including G protein-coupled receptor binding activity; GTP binding activity; and GTPase activating protein binding activity. Involved in several processes, including nervous system development; positive regulation of GTPase activity; and response to hydrogen peroxide. Located in myelin sheath. Is active in parallel fiber to Purkinje cell synapse and synaptic vesicle membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 17 and neurodevelopmental disorder with involuntary movements. Orthologous to human GNAO1 (G protein subunit alpha o1).
RGD Description
Enables several functions, including G protein-coupled receptor binding activity; GTP binding activity; and GTPase activating protein binding activity. Involved in several processes, including nervous system development; positive regulation of GTPase activity; and response to hydrogen peroxide. Located in myelin sheath. Is active in parallel fiber to Purkinje cell synapse and synaptic vesicle membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 17 and neurodevelopmental disorder with involuntary movements. Orthologous to human GNAO1 (G protein subunit alpha o1); PARTICIPATES IN G protein mediated signaling pathway; dopamine signaling pathway via D2 family of receptors; endothelin signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10218
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Gnao1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Gnao1 role
            Gnao1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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