Gene

Npc2

Species
Rattus norvegicus
Symbol
Npc2
Name
NPC intracellular cholesterol transporter 2
Synonyms
  • epididymal secretory protein 1
  • epididymal secretory protein E1
Biotype
protein coding gene
Automated Description
Predicted to enable cholesterol binding activity; cholesterol transfer activity; and enzyme binding activity. Predicted to be involved in cholesterol homeostasis; cholesterol transport; and response to virus. Predicted to act upstream of or within several processes, including cholesterol storage; sterol metabolic process; and sterol transport. Predicted to be located in extracellular space. Predicted to be active in lysosome. Human ortholog(s) of this gene implicated in Niemann-Pick disease and Niemann-Pick disease type C2. Orthologous to human NPC2 (NPC intracellular cholesterol transporter 2).
RGD Description
Predicted to enable cholesterol binding activity; cholesterol transfer activity; and enzyme binding activity. Predicted to be involved in cholesterol homeostasis; cholesterol transport; and response to virus. Predicted to act upstream of or within several processes, including cholesterol storage; sterol metabolic process; and sterol transport. Predicted to be located in extracellular space. Predicted to be active in lysosome. Human ortholog(s) of this gene implicated in Niemann-Pick disease and Niemann-Pick disease type C2. Orthologous to human NPC2 (NPC intracellular cholesterol transporter 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 4,4'-sulfonyldiphenol.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11306
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
104.380M104.385M104.390M104.395M104.400M104.405M104.410M104.415M

Sequence Details

Loading...

Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions