Version: 8.0.0
Date: Tue Jan 28 2025
Bcl2l11
Rattus norvegicusRGD:628774
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Bcl2l11

Species
Rattus norvegicus
Symbol
Bcl2l11
Name
Bcl2-like 11
Synonyms
  • Bcl-2 related apoptotic gene product BimL
  • bcl-2-like protein 11
Biotype
protein coding gene
Automated Description
Predicted to enable protein kinase binding activity. Predicted to contribute to microtubule binding activity. Involved in several processes, including cellular response to amyloid-beta; cellular response to estradiol stimulus; and positive regulation of autophagy in response to ER overload. Predicted to be located in several cellular components, including cytosol; intracellular membrane-bounded organelle; and microtubule. Predicted to be part of BIM-BCL-2 complex and BIM-BCL-xl complex. Predicted to be active in mitochondrion. Orthologous to human BCL2L11 (BCL2 like 11).
RGD Description
Predicted to enable protein kinase binding activity. Predicted to contribute to microtubule binding activity. Involved in several processes, including cellular response to amyloid-beta; cellular response to estradiol stimulus; and positive regulation of autophagy in response to ER overload. Predicted to be located in several cellular components, including cytosol; intracellular membrane-bounded organelle; and microtubule. Predicted to be part of BIM-BCL-2 complex and BIM-BCL-xl complex. Predicted to be active in mitochondrion. Orthologous to human BCL2L11 (BCL2 like 11); PARTICIPATES IN intrinsic apoptotic pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12044
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Bcl2l11 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Bcl2l11 role
            Bcl2l11 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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