Gene

Nr1d1

Species
Rattus norvegicus
Symbol
Nr1d1
Name
nuclear receptor subfamily 1, group D, member 1
Synonyms
  • EAR-1
  • nuclear receptor subfamily 1 group D member 1
Biotype
protein coding gene
Automated Description
Enables transcription cis-regulatory region binding activity. Involved in several processes, including photoperiodism; positive regulation of circadian rhythm; and regulation of hepatic stellate cell activation. Located in dendrite and neuronal cell body. Biomarker of hyperthyroidism; hypothyroidism; portal hypertension; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in brain small vessel disease. Orthologous to human NR1D1 (nuclear receptor subfamily 1 group D member 1).
RGD Description
Enables transcription cis-regulatory region binding activity. Involved in several processes, including photoperiodism; positive regulation of circadian rhythm; and regulation of hepatic stellate cell activation. Located in dendrite and neuronal cell body. Biomarker of hyperthyroidism; hypothyroidism; portal hypertension; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in brain small vessel disease. Orthologous to human NR1D1 (nuclear receptor subfamily 1 group D member 1); INTERACTS WITH 1,2,4-trimethylbenzene; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24082
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
83.729M83.730M83.731M83.732M83.733M83.734M83.735M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions