Gene

Slc17a8

Species
Rattus norvegicus
Symbol
Slc17a8
Name
solute carrier family 17 member 8
Synonyms
  • solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8
  • solute carrier family 17 (vesicular glutamate transporter), member 8
Biotype
protein coding gene
Automated Description
Enables L-glutamate uniporter activity and chloride channel activity. Involved in several processes, including L-glutamate transmembrane transport; cochlea development; and regulation of acetylcholine uptake. Located in several cellular components, including axon; cytoplasmic vesicle; and dendrite. Biomarker of Parkinsonism; cochlear disease; sciatic neuropathy; transient cerebral ischemia; and trichinosis. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 25. Orthologous to human SLC17A8 (solute carrier family 17 member 8).
RGD Description
Enables L-glutamate uniporter activity and chloride channel activity. Involved in several processes, including L-glutamate transmembrane transport; cochlea development; and regulation of acetylcholine uptake. Located in several cellular components, including axon; cytoplasmic vesicle; and dendrite. Biomarker of Parkinsonism; cochlear disease; sciatic neuropathy; transient cerebral ischemia; and trichinosis. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 25. Orthologous to human SLC17A8 (solute carrier family 17 member 8); PARTICIPATES IN auditory mechanotransduction pathway; glutamate signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11662
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
23.995M24.000M24.005M24.010M24.015M24.020M24.025M24.030M24.035M24.040M24.045M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions