Gene

Sharpin

Species
Rattus norvegicus
Symbol
Sharpin
Name
SHANK-associated RH domain interactor
Synonyms
  • Conneck1
  • MGC93373
Biotype
protein coding gene
Automated Description
Enables identical protein binding activity. Predicted to be involved in several processes, including proteasome-mediated ubiquitin-dependent protein catabolic process; protein linear polyubiquitination; and regulation of signal transduction. Predicted to act upstream of or within apoptotic nuclear changes; keratinization; and mitochondrion organization. Located in dendrite. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human SHARPIN (SHANK associated RH domain interactor).
RGD Description
Enables identical protein binding activity. Predicted to be involved in several processes, including proteasome-mediated ubiquitin-dependent protein catabolic process; protein linear polyubiquitination; and regulation of signal transduction. Predicted to act upstream of or within apoptotic nuclear changes; keratinization; and mitochondrion organization. Located in dendrite. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human SHARPIN (SHANK associated RH domain interactor); PARTICIPATES IN integrin mediated signaling pathway; nuclear factor kappa B signaling pathway; tumor necrosis factor mediated signaling pathway; INTERACTS WITH 2,4-dinitrotoluene; ammonium chloride; bisphenol A.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR22770
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
108.0710M108.0715M108.0720M108.0725M108.0730M108.0735M108.0740M108.0745M108.0750M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions