Gene

Sharpin

Species
Rattus norvegicus
Symbol
Sharpin
Name
SHANK-associated RH domain interactor
Synonyms
  • Conneck1
  • MGC93373
Biotype
protein coding gene
Automated Description
Enables identical protein binding activity. Predicted to be involved in several processes, including proteasome-mediated ubiquitin-dependent protein catabolic process; protein linear polyubiquitination; and regulation of signal transduction. Predicted to act upstream of or within apoptotic nuclear changes; keratinization; and mitochondrion organization. Located in dendrite. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human SHARPIN (SHANK associated RH domain interactor).
RGD Description
Enables identical protein binding activity. Predicted to be involved in several processes, including proteasome-mediated ubiquitin-dependent protein catabolic process; protein linear polyubiquitination; and regulation of signal transduction. Predicted to act upstream of or within apoptotic nuclear changes; keratinization; and mitochondrion organization. Located in dendrite. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human SHARPIN (SHANK associated RH domain interactor); PARTICIPATES IN integrin mediated signaling pathway; nuclear factor kappa B signaling pathway; tumor necrosis factor mediated signaling pathway; INTERACTS WITH 2,4-dinitrotoluene; ammonium chloride; bisphenol A.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR22770
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensSHARPIN10 of 10YesYes  
Mus musculusSharpin9 of 9YesYes   
Danio reriosharpin5 of 9YesYes   
Danio rerioshrprbck1r3 of 9NoYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Rbck1122355393 of 9 
Rnf216234733243 of 9 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

Species
(carrying the transgene)
Allele symbol
Transgenic construct
Expressed components
Knock-down targets
Regulatory regions
Has Disease Annotations
Has Phenotype Annotations
Mus musculusTg(RP24-173I23)1Sun
Yes
Showing 1 - 1 of 1 rows
per page

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
108.0710M108.0715M108.0720M108.0725M108.0730M108.0735M108.0740M108.0745M108.0750M

Sequence Details

Loading...

Expression

Primary Sources
None
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

9 interactor genes based on 18 annotations
Sharpin molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
Dlg4Rattus norvegicus
protein
  • anti bait coimmunoprecipitation
PMID:11178875
protein
Dlg4Rattus norvegicus
protein
  • confocal microscopy
PMID:11178875
protein
Grip1Rattus norvegicus
protein
  • anti bait coimmunoprecipitation
PMID:11178875
protein
ITGA1Homo sapiens
protein
  • pull down
PMID:21947080
protein
ITGA2Homo sapiens
protein
  • pull down
PMID:21947080
protein
RNF31Homo sapiens
protein
  • affinity chromatography technology
PMID:22253853
protein
RNF31Homo sapiens
protein
  • affinity chromatography technology
PMID:22253853
protein
Shank1Rattus norvegicus
protein
  • two hybrid
PMID:11178875
protein
Shank1Rattus norvegicus
protein
  • anti bait coimmunoprecipitation
PMID:11178875
protein
Shank1Rattus norvegicus
protein
  • anti bait coimmunoprecipitation
PMID:11178875
Showing 1 - 10 of 18 rows
per page

Genetic Interactions

No data available