Version: 8.1.0Date: Fri Apr 18 2025
Gene
Egln1
- Species
- Rattus norvegicus
- Symbol
- Egln1
- Name
- egl-9 family hypoxia-inducible factor 1
- Synonyms
- egl nine homolog 1
- EGL nine homolog 1 (C. elegans)
- Biotype
- protein coding gene
- Automated Description
- Enables enzyme binding activity and peptidyl-proline dioxygenase activity. Involved in several processes, including negative regulation of CAMKK-AMPK signaling cascade; negative regulation of DNA-binding transcription factor activity; and negative regulation of cyclic-nucleotide phosphodiesterase activity. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be active in several cellular components, including glutamatergic synapse; nucleus; and postsynaptic density. Used to study hypertension. Biomarker of acute kidney failure and myocardial infarction. Human ortholog(s) of this gene implicated in familial erythrocytosis 3; polycythemia; and renal cell carcinoma. Orthologous to human EGLN1 (egl-9 family hypoxia inducible factor 1).
- RGD Description
- Enables enzyme binding activity and peptidyl-proline dioxygenase activity. Involved in several processes, including negative regulation of CAMKK-AMPK signaling cascade; negative regulation of DNA-binding transcription factor activity; and negative regulation of cyclic-nucleotide phosphodiesterase activity. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be active in several cellular components, including glutamatergic synapse; nucleus; and postsynaptic density. Used to study hypertension. Biomarker of acute kidney failure and myocardial infarction. Human ortholog(s) of this gene implicated in familial erythrocytosis 3; polycythemia; and renal cell carcinoma. Orthologous to human EGLN1 (egl-9 family hypoxia inducible factor 1); PARTICIPATES IN hypoxia inducible factor pathway; vascular endothelial growth factor signaling pathway; renal cell carcinoma pathway; INTERACTS WITH 2,6-dinitrotoluene; 6-propyl-2-thiouracil; amitrole.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR12907
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr19:52867900...52907777 - (39.88 kb)
- Assembly version
- mRatBN7.2
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.