Species

Rattus norvegicus

Symbol

Slu7

Name

SLU7 homolog, splicing factor

Synonyms

DNA segment, Chr 11, ERATO Doi 730, expressed
DNA segment, Chr 3, Brigham & Womens Genetics 0878 expressed

Biotype

protein coding gene

Automated Description

Predicted to enable pre-mRNA 3'-splice site binding activity; second spliceosomal transesterification activity; and zinc ion binding activity. Predicted to be involved in cellular response to heat; intracellular protein transport; and mRNA splicing, via spliceosome. Predicted to be located in cytosol and nuclear speck. Predicted to be part of catalytic step 2 spliceosome and small nuclear ribonucleoprotein complex. Orthologous to human SLU7 (SLU7 homolog, splicing factor).

RGD Description

Predicted to enable pre-mRNA 3'-splice site binding activity; second spliceosomal transesterification activity; and zinc ion binding activity. Predicted to be involved in cellular response to heat; intracellular protein transport; and mRNA splicing, via spliceosome. Predicted to be located in cytosol and nuclear speck. Predicted to be part of catalytic step 2 spliceosome and small nuclear ribonucleoprotein complex. Orthologous to human SLU7 (SLU7 homolog, splicing factor); PARTICIPATES IN spliceosome pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.

Cross References

Additional Information

Literature

Orthology

Gene tree: PANTHER:PTHR12942

Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse

Paralogy

Function - GO Annotations

Show functions with at least one experimental evidence

Pathways

No data available

Phenotypes

Primary Sources: None
Other Sources: None

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Disease Associations

Include negative annotationsCases where the expected disease association was NOT found

Cell color indicative of annotation volume

Alleles and Variants

Allele/Variant Symbol	Allele Synonyms	Category	Variant	Variant type	Molecular consequence	Has Disease Annotations	Has Phenotype Annotations
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Transgenic Alleles

Species (carrying the transgene)	Allele symbol	Transgenic construct	Expressed components	Knock-down targets	Regulatory regions	Has Disease Annotations	Has Phenotype Annotations
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Models

Model name	Experimental condition	Associated Human Diseases	Associated Phenotypes	Modifier	Source
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Sequence Feature Viewer

Genome location

Chr10:27908325...27923784 + (15.46 kb)

Assembly version

mRatBN7.2

Viewer Help

Data currently unavailable; sequence viewer under construction

Sequence Details

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Expression

Primary Sources

None

Other Sources

Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Slu7 molecule type	Interactor gene	Interactor species	Interactor molecule type	Detection method	Source	Reference
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Genetic Interactions

Slu7 role	Slu7 genetic perturbation	Interactor gene	Interactor species	Interactor role	Interactor genetic perturbation	Interaction type	Phenotype or trait	Source	Reference
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