Version: 8.0.0
Date: Tue Jan 28 2025
Pla2g4a
Rattus norvegicusRGD:67366
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Pla2g4a

Species
Rattus norvegicus
Symbol
Pla2g4a
Name
phospholipase A2 group 4A
Synonyms
  • cPLA2
  • cytosolic phospholipase A2
Biotype
protein coding gene
Automated Description
Enables calcium-dependent phospholipase A2 activity and histone acetyltransferase binding activity. Involved in several processes, including cellular response to homocysteine; decidualization; and female gonad development. Located in perinuclear region of cytoplasm and zymogen granule. Used to study hyperglycemia. Biomarker of asthma; brain ischemia; papilloma; polycystic kidney disease; and transitional cell carcinoma. Orthologous to human PLA2G4A (phospholipase A2 group IVA).
RGD Description
Enables calcium-dependent phospholipase A2 activity and histone acetyltransferase binding activity. Involved in several processes, including cellular response to homocysteine; decidualization; and female gonad development. Located in perinuclear region of cytoplasm and zymogen granule. Used to study hyperglycemia. Biomarker of asthma; brain ischemia; papilloma; polycystic kidney disease; and transitional cell carcinoma. Orthologous to human PLA2G4A (phospholipase A2 group IVA); PARTICIPATES IN cyclooxygenase mediated pathway of arachidonic acid metabolism; endothelin signaling pathway; Fc epsilon receptor mediated signaling pathway; INTERACTS WITH (S)-nicotine; 1,2,3,4-tetrahydroisoquinoline; 1-naphthyl isothiocyanate.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10728
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Pla2g4a molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Pla2g4a role
            Pla2g4a genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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