Version: 8.0.0
Date: Tue Jan 28 2025
Acaa1a
Rattus norvegicusRGD:67379
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Acaa1a

Species
Rattus norvegicus
Symbol
Acaa1a
Name
acetyl-CoA acyltransferase 1A
Synonyms
  • 3-ketoacyl-CoA thiolase A, peroxisomal
  • Acaa
Biotype
protein coding gene
Automated Description
Enables acetyl-CoA C-acyltransferase activity; acetyl-CoA C-myristoyltransferase activity; and palmitoyl-CoA oxidase activity. Involved in several processes, including monocarboxylic acid metabolic process; response to nutrient; and response to steroid hormone. Located in peroxisome. Orthologous to human ACAA1 (acetyl-CoA acyltransferase 1).
RGD Description
Enables acetyl-CoA C-acyltransferase activity; acetyl-CoA C-myristoyltransferase activity; and palmitoyl-CoA oxidase activity. Involved in several processes, including monocarboxylic acid metabolic process; response to nutrient; and response to steroid hormone. Located in peroxisome. Orthologous to human ACAA1 (acetyl-CoA acyltransferase 1); PARTICIPATES IN eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; fatty acid metabolic pathway; unsaturated fatty acid biosynthetic pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR43853
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          mRatBN7.2
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Acaa1a molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Acaa1a role
            Acaa1a genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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