Version: 8.0.0Date: Tue Jan 28 2025
Gene
Prkcd
- Species
- Rattus norvegicus
- Symbol
- Prkcd
- Name
- protein kinase C, delta
- Synonyms
- nPKC-delta
- Pkcd
- Biotype
- protein coding gene
- Automated Description
- Enables TIR domain binding activity; diacylglycerol-dependent, calcium-independent serine/threonine kinase activity; and protein kinase binding activity. Involved in several processes, including D-aspartate import across plasma membrane; positive regulation of D-glucose import; and positive regulation of MAP kinase activity. Is active in postsynaptic cytosol. Used to study brain ischemia and hypertension. Biomarker of hyperinsulinism; hypertension; muscular disease; obesity; and restrictive cardiomyopathy. Human ortholog(s) of this gene implicated in autoimmune lymphoproliferative syndrome type 3 and steatotic liver disease. Orthologous to human PRKCD (protein kinase C delta).
- RGD Description
- Enables TIR domain binding activity; diacylglycerol-dependent, calcium-independent serine/threonine kinase activity; and protein kinase binding activity. Involved in several processes, including D-aspartate import across plasma membrane; positive regulation of D-glucose import; and positive regulation of MAP kinase activity. Is active in postsynaptic cytosol. Used to study brain ischemia and hypertension. Biomarker of hyperinsulinism; hypertension; muscular disease; obesity; and restrictive cardiomyopathy. Human ortholog(s) of this gene implicated in autoimmune lymphoproliferative syndrome type 3 and steatotic liver disease. Orthologous to human PRKCD (protein kinase C delta); PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signaling pathway; vascular endothelial growth factor signaling pathway; ceramide signaling pathway; INTERACTS WITH (+)-pilocarpine; (S)-amphetamine; 1-(5-isoquinolinesulfonyl)-2-methylpiperazine.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR24356
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- None
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr16:5769215...5799380 - (30.17 kb)
- Assembly version
- mRatBN7.2
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.