Version: 8.0.0
Date: Tue Jan 28 2025
Prkcd
Rattus norvegicusRGD:67383
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Prkcd

Species
Rattus norvegicus
Symbol
Prkcd
Name
protein kinase C, delta
Synonyms
  • nPKC-delta
  • Pkcd
Biotype
protein coding gene
Automated Description
Enables TIR domain binding activity; diacylglycerol-dependent, calcium-independent serine/threonine kinase activity; and protein kinase binding activity. Involved in several processes, including D-aspartate import across plasma membrane; positive regulation of D-glucose import; and positive regulation of MAP kinase activity. Is active in postsynaptic cytosol. Used to study brain ischemia and hypertension. Biomarker of hyperinsulinism; hypertension; muscular disease; obesity; and restrictive cardiomyopathy. Human ortholog(s) of this gene implicated in autoimmune lymphoproliferative syndrome type 3 and steatotic liver disease. Orthologous to human PRKCD (protein kinase C delta).
RGD Description
Enables TIR domain binding activity; diacylglycerol-dependent, calcium-independent serine/threonine kinase activity; and protein kinase binding activity. Involved in several processes, including D-aspartate import across plasma membrane; positive regulation of D-glucose import; and positive regulation of MAP kinase activity. Is active in postsynaptic cytosol. Used to study brain ischemia and hypertension. Biomarker of hyperinsulinism; hypertension; muscular disease; obesity; and restrictive cardiomyopathy. Human ortholog(s) of this gene implicated in autoimmune lymphoproliferative syndrome type 3 and steatotic liver disease. Orthologous to human PRKCD (protein kinase C delta); PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signaling pathway; vascular endothelial growth factor signaling pathway; ceramide signaling pathway; INTERACTS WITH (+)-pilocarpine; (S)-amphetamine; 1-(5-isoquinolinesulfonyl)-2-methylpiperazine.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24356
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
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            Sequence Feature Viewer

            Genome location
            Assembly version
            mRatBN7.2
            Viewer Help
            5.770M5.775M5.780M5.785M5.790M5.795M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Prkcd molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              Prkcd role
              Prkcd genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
              Reference
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