Gene

Gipc1

Species
Rattus norvegicus
Symbol
Gipc1
Name
GIPC PDZ domain containing family, member 1
Synonyms
  • GAIP C-terminus-interacting protein
  • Gipc
Biotype
protein coding gene
Automated Description
Enables PDZ domain binding activity. Predicted to be involved in several processes, including negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of melanin biosynthetic process; and positive regulation of transforming growth factor beta receptor signaling pathway. Predicted to act upstream of or within several processes, including cellular response to interleukin-7; endothelial cell migration; and glutamate secretion. Located in brush border and endocytic vesicle. Is active in Schaffer collateral - CA1 synapse; postsynapse; and presynapse. Human ortholog(s) of this gene implicated in oculopharyngodistal myopathy 2. Orthologous to human GIPC1 (GIPC PDZ domain containing family member 1).
RGD Description
Enables PDZ domain binding activity. Predicted to be involved in positive regulation of cytokinesis and positive regulation of melanin biosynthetic process. Located in brush border and endocytic vesicle. Is active in Schaffer collateral - CA1 synapse; postsynapse; and presynapse. Human ortholog(s) of this gene implicated in oculopharyngodistal myopathy 2. Orthologous to human GIPC1 (GIPC PDZ domain containing family member 1); PARTICIPATES IN syndecan signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12259
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
24.455M24.460M24.465M24.470M24.475M24.480M24.485M

Sequence Details

Loading...

Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions