Gene

Lrat

Species
Rattus norvegicus
Symbol
Lrat
Name
lecithin retinol acyltransferase
Synonyms
  • lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
  • lecithin-retinol acyltransferase
Biotype
protein coding gene
Automated Description
Enables phosphatidylcholine-retinol O-acyltransferase activity; retinoic acid binding activity; and retinol binding activity. Involved in response to retinoic acid; response to vitamin A; and retinol metabolic process. Located in multivesicular body; perinuclear region of cytoplasm; and rough endoplasmic reticulum. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 14 and retinitis pigmentosa. Orthologous to human LRAT (lecithin retinol acyltransferase).
RGD Description
Enables phosphatidylcholine-retinol O-acyltransferase activity; retinoic acid binding activity; and retinol binding activity. Involved in response to retinoic acid; response to vitamin A; and retinol metabolic process. Located in multivesicular body; perinuclear region of cytoplasm; and rough endoplasmic reticulum. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 14 and retinitis pigmentosa. Orthologous to human LRAT (lecithin retinol acyltransferase); PARTICIPATES IN altered retinoid cycle metabolic pathway; retinitis pigmentosa pathway; retinoic acid metabolic pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR46678
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
168.265M168.266M168.267M168.268M168.269M168.270M168.271M168.272M168.273M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions