Gene

Ltbp1

Species
Rattus norvegicus
Symbol
Ltbp1
Name
latent transforming growth factor beta binding protein 1
Synonyms
  • LanC (bacterial lantibiotic synthetase component C)-like 1
  • latent-transforming growth factor beta-binding protein 1
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including microfibril binding activity; receptor ligand inhibitor activity; and transforming growth factor beta binding activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to parathyroid hormone stimulus; and cellular response to platelet-derived growth factor stimulus. Located in several cellular components, including dendrite; neuronal cell body; and perinuclear region of cytoplasm. Part of large latent transforming growth factor-beta complex. Biomarker of glomerulonephritis and transient cerebral ischemia. Human ortholog(s) of this gene implicated in cutis laxa. Orthologous to human LTBP1 (latent transforming growth factor beta binding protein 1).
RGD Description
Predicted to enable several functions, including microfibril binding activity; receptor ligand inhibitor activity; and transforming growth factor beta binding activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to parathyroid hormone stimulus; and cellular response to platelet-derived growth factor stimulus. Located in several cellular components, including dendrite; neuronal cell body; and perinuclear region of cytoplasm. Part of large latent transforming growth factor-beta complex. Biomarker of glomerulonephritis and transient cerebral ischemia. Human ortholog(s) of this gene implicated in cutis laxa. Orthologous to human LTBP1 (latent transforming growth factor beta binding protein 1); PARTICIPATES IN transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR47333
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
20.05M20.10M20.15M20.20M20.25M20.30M20.35M20.40M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions