Gene

Pfkm

Species
Rattus norvegicus
Symbol
Pfkm
Name
phosphofructokinase, muscle
Synonyms
  • 6-phosphofructokinase type A
  • 6-phosphofructokinase, muscle type
Biotype
protein coding gene
Automated Description
Enables several functions, including 6-phosphofructokinase activity; anion binding activity; and identical protein binding activity. Involved in fructose 1,6-bisphosphate metabolic process; fructose 6-phosphate metabolic process; and glycolytic process. Predicted to be located in apical plasma membrane; nucleus; and sperm principal piece. Predicted to be part of 6-phosphofructokinase complex. Predicted to be active in cytosol and membrane. Human ortholog(s) of this gene implicated in glycogen storage disease VII. Orthologous to human PFKM (phosphofructokinase, muscle).
RGD Description
Enables several functions, including 6-phosphofructokinase activity; anion binding activity; and identical protein binding activity. Involved in fructose 1,6-bisphosphate metabolic process; fructose 6-phosphate metabolic process; and glycolytic process. Predicted to be located in apical plasma membrane; nucleus; and sperm principal piece. Predicted to be part of 6-phosphofructokinase complex. Predicted to be active in cytosol and membrane. Human ortholog(s) of this gene implicated in glycogen storage disease VII. Orthologous to human PFKM (phosphofructokinase, muscle); PARTICIPATES IN Fanconi syndrome pathway; glycogen storage disease type VII pathway; glycolysis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-Tetrachlorodibenzofuran; 2,4-D.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13697
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
129.225M129.230M129.235M129.240M129.245M129.250M129.255M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions