Gene

Cldn1

Species
Rattus norvegicus
Symbol
Cldn1
Name
claudin 1
Synonyms
  • claudin-1
Biotype
protein coding gene
Automated Description
Predicted to enable identical protein binding activity and virus receptor activity. Involved in several processes, including cellular response to butyrate; cellular response to cytokine stimulus; and endothelial cell development. Located in apical plasma membrane; bicellular tight junction; and lateral plasma membrane. Biomarker of diabetic retinopathy; liver disease (multiple); and periodontitis. Human ortholog(s) of this gene implicated in Crohn's disease and atopic dermatitis. Orthologous to human CLDN1 (claudin 1).
RGD Description
Predicted to enable identical protein binding activity and virus receptor activity. Involved in several processes, including cellular response to butyrate; cellular response to cytokine stimulus; and endothelial cell development. Located in apical plasma membrane; bicellular tight junction; and lateral plasma membrane. Biomarker of diabetic retinopathy; liver disease (multiple); and periodontitis. Human ortholog(s) of this gene implicated in Crohn's disease and atopic dermatitis. Orthologous to human CLDN1 (claudin 1); PARTICIPATES IN hepatitis C pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12002
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
mRatBN7.2
Viewer Help
74.422M74.424M74.426M74.428M74.430M74.432M74.434M74.436M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions