Enables chloride channel activity and voltage-gated monoatomic ion channel activity. Involved in several processes, including body fluid secretion; response to calcium ion; and response to pH. Located in apical plasma membrane and basolateral plasma membrane. Human ortholog(s) of this gene implicated in Bartter disease type 3; Bartter disease type 4b; Gitelman syndrome; hypertension; and sensorineural hearing loss. Orthologous to human CLCNKA (chloride voltage-gated channel Ka) and CLCNKB (chloride voltage-gated channel Kb).
RGD Description
Enables chloride channel activity and voltage-gated monoatomic ion channel activity. Involved in several processes, including body fluid secretion; response to calcium ion; and response to pH. Located in apical plasma membrane and basolateral plasma membrane. Human ortholog(s) of this gene implicated in Bartter disease type 3; Bartter disease type 4b; Gitelman syndrome; hypertension; and sensorineural hearing loss. Orthologous to human CLCNKA (chloride voltage-gated channel Ka) and CLCNKB (chloride voltage-gated channel Kb); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; INTERACTS WITH (4-chloro-2-methylphenoxy)acetic acid; 4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid; 6-propyl-2-thiouracil.