Version: 8.0.0Date: Tue Jan 28 2025
Gene
Cdkn1b
- Species
- Rattus norvegicus
- Symbol
- Cdkn1b
- Name
- cyclin-dependent kinase inhibitor 1B
- Synonyms
- Cdki1b
- CDKN4
- Biotype
- protein coding gene
- Automated Description
- Enables Hsp70 protein binding activity. Involved in several processes, including cellular response to hypoxia; negative regulation of vascular associated smooth muscle cell proliferation; and regulation of cyclin-dependent protein serine/threonine kinase activity. Part of protein-containing complex. Used to study cataract; endocrine organ benign neoplasm (multiple); infertility; multiple endocrine neoplasia; and myocardial infarction. Biomarker of several diseases, including acute kidney failure; glomerulonephritis (multiple); obesity; pulmonary hypertension; and sciatic neuropathy. Human ortholog(s) of this gene implicated in acute myeloid leukemia; breast cancer; multiple endocrine neoplasia type 4; and myelodysplastic syndrome. Orthologous to human CDKN1B (cyclin dependent kinase inhibitor 1B).
- RGD Description
- Enables Hsp70 protein binding activity. Involved in several processes, including negative regulation of vascular associated smooth muscle cell proliferation; regulation of cyclin-dependent protein serine/threonine kinase activity; and response to estradiol. Part of protein-containing complex. Used to study cataract; endocrine organ benign neoplasm (multiple); infertility; multiple endocrine neoplasia; and myocardial infarction. Biomarker of several diseases, including acute kidney failure; glomerulonephritis (multiple); obesity; pulmonary hypertension; and sciatic neuropathy. Human ortholog(s) of this gene implicated in acute myeloid leukemia; breast cancer; multiple endocrine neoplasia type 4; and myelodysplastic syndrome. Orthologous to human CDKN1B (cyclin dependent kinase inhibitor 1B); PARTICIPATES IN forkhead class A signaling pathway; G1/S transition pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; INTERACTS WITH (+)-pilocarpine; (Z)-3-butylidenephthalide; 1,2-dimethylhydrazine.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR10265
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr4:167760067...167765177 + (5.11 kb)
- Assembly version
- mRatBN7.2
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.